5-Chloro-2-methylaniline Chemical Properties

Melting point:

22 °C

Boiling point:

237 °C(lit.)

Density 

1.177 g/mL at 20 °C(lit.)

vapor pressure 

0.45 hPa (50 °C)

refractive index 

n20/D 1.584(lit.)

Flash point:

320 °F

storage temp. 

Store below +30°C.

solubility 

soluble in Alcohol

form 

Liquid After Melting

pka

pK1:3.85(+1) (25°C)

color 

Clear yellow to light brown

Water Solubility 

< 1 g/L (22 ºC)

BRN 

878504

CAS DataBase Reference

95-79-4(CAS DataBase Reference)

NIST Chemistry Reference

Benzenamine, 5-chloro-2-methyl-(95-79-4)

IARC

3 (Vol. 77, 99) 2010

EPA Substance Registry System

5-Chloro-2-methylaniline (95-79-4)

Safety Information

Hazard Codes 

Xn,T

Risk Statements 

22-36/37/38-40-45-23/24/25

Safety Statements 

26-45-36/37/39-53

RIDADR 

UN 3429 6.1/PG 3

WGK Germany 

3

RTECS 

XU5075000

Autoignition Temperature

>540 °C

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29214300

Hazardous Substances Data

95-79-4(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: 464 mg/kg

MSDS

• Language:English Provider:2-Amino-4-chlorotoluene
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

5-Chloro-2-methylaniline Usage And Synthesis

Chemical Properties

clear yellow to light brown liquid after melting

Chemical Properties

The chloromethylanilines are colorless or white crystalline solids or liquids, some have a mild fishy odor.

Uses

5-Chloro-2-toluidine, is a versatile building block used for the synthesis of various pharmaceutical and biologically active compounds including inhibitors. It is a carcinogenic monocyclic amine. The compound is used in synthesizing dyes.

Definition

ChEBI: 5-Chloro-ortho-toluidine is a member of monochlorobenzenes.

Potential Exposure

Most of the isomers are used in dyestuff manufacture. The 3-chloro-para isomer is used to kill birds. It is marketed as pelleted bait for control of bird populations.

Carcinogenicity

A bioassay for the possible carcinogenicity of 5-chloro-otoluidine was conducted using Fischer 344 rats and B6C3F1 mice. Groups of 50 male and 50 female rats and mice were given 5-chloro-o-toluidine in the diet at 2500 or 5000 ppm for rats and 2000 or 4000 ppm for mice. The compound was administered for 78 weeks to both rats and mice, followed by an observation period of up to 26 weeks for rats and 13 weeks for mice. Under the conditions of this bioassay, 5-chloro-otoluidine was carcinogenic to the mice, inducing hemangiosarcomas and hepatocellular carcinomas in both males and females. There was no conclusive evidence of the carcinogenicity of the compound in the rats.

Shipping

UN2239 Chlorotoluidines, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3429 Chlorotoluidines, liquid, Hazard Class: 6.1; Labels: 6.1- Poisonous materials

Incompatibilities

Incompatible with oxidizers, strong acids; chloroformates, and acid anhydrides, isocyanates, aldehydes forming fire and explosive hazards.

5-Chloro-2-methylaniline(95-79-4)Related Product Information

• Toluidine Blue O
• o-Toluidine
• Glycine
• Pigment Red 3
• Betaine
• ALTRENOGEST
• Epichlorohydrin
• N-Methylaniline
• FAST RED VIOLET LB BASE
• 4-Chloro-2-nitrotoluene
• 2-AMINO-4-CHLOROBENZOIC ACID
• 4-CHLORO-2-NITROBENZYL ALCOHOL
• Difluorochloromethane
• Chloroacetic acid
• 4-Chloro-2-methylaniline
• METHYL 4-CHLORO-2-NITROBENZOATE
• 2-Amino-4-chlorobenzoic acid
• Furosemide