3-Hydroxypiperidine Chemical Properties

Melting point:

57-61 °C

Boiling point:

67-69 °C (2 mmHg)

Density 

1.016±0.06 g/cm3(Predicted)

Flash point:

>100°C

storage temp. 

2-8°C

solubility 

ethanol: 0.1 g/mL, clear

pka

14.91±0.20(Predicted)

form 

Crystalline Powder and Lumps

color 

White to light yellow

PH

11.5-11.7 (H2O)Aqueous solution

Water Solubility 

soluble

Sensitive 

Air Sensitive & Hygroscopic

BRN 

102696

InChIKey

BIWOSRSKDCZIFM-UHFFFAOYSA-N

LogP

-0.35

CAS DataBase Reference

6859-99-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

34-20/21/22-36/37/38

Safety Statements 

26-36/37/39-45-27

RIDADR 

UN 3263 8/PG 2

WGK Germany 

3

HazardClass 

8

PackingGroup 

III

HS Code 

29333990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3-Hydroxypiperidine Usage And Synthesis

Background

Many piperidine derivatives have multiple pharmacological activities such as antibacterial, antitumor, treatment of Alzheimer's disease and anesthesia. They are also important drugs for the treatment of viral infections (including AIDS) and diabetes. 3-Hydroxypiperidine or its derivatives are one of the important intermediates, which are widely used in the synthesis of drug intermediates such as chiral 3-aminopiperidine. It is of great significance to develop a synthesis method suitable for industrial production.

Chemical Properties

White to light yellow crystalline powder and lumps

Application

3-Hydroxypiperidine may be used to synthesize the following:
2-pyrrolidinone via oxidation with iodosylbenzene
1-[2,8-bis(trifluoromethyl)quinolin-4-yl]piperidin-3-ol via reaction with 4-bromoquinoline
Reactant for:
Synthesis of unsymmetrical ureas
Synthesis of piperidine nucleoside analogs
Fluorination reactions
Synthesis of substituted pyridines

Uses

3-Hydroxypiperidine is usually used for Synthesis of unsymmetrical ureas,Synthesis of piperidine nucleoside analogs,Fluorination reactions,Synthesis of substituted pyridines.

General Description

3-Hydroxypiperidine can be obtained from the reduction of 3-hydroxypyridine.

Synthesis

Dissolve 86.0g of 5-bromo-2-hydroxypentylamine hydrobromide in 150mL of water, and add a solution of 60mL of water containing 15.0g of sodium carbonate at 10-15°C, and drip it for about 1 hour. After dripping, react at about 15°C for 2 hours. Then heat to 30-40°C and react for 2 hours. Stop the reaction, cool it to room temperature, and concentrate the reaction solution under reduced pressure to remove most of the water. Filter it to remove salt, wash it with cold water, and continue to concentrate the mother liquor. The crude product is distilled under reduced pressure to obtain 26.5g of colourless oily 3-hydroxypiperidine, yielding 80%.

3-Hydroxypiperidine(6859-99-0)Related Product Information

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