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3-Methoxysalicylaldehyde

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3-Methoxysalicylaldehyde Basic information

Product Name:
3-Methoxysalicylaldehyde
Synonyms:
  • TIMTEC-BB SBB000109
  • O-VANILLIN (2-HYDROXY-3-METHOXYBENZALDEHYDE)
  • 2-Hydroxy-3-methoxybenzaldehyde, 2-Hydroxy-m-anisaldehyde, 3-Methoxysalicylaldehyde
  • 2-HYDROXY-3-METHOXYBENZALDEHYDE / O-VANILLIN
  • Adjacent vanillin
  • 3-Methoxysalicyladehyde
  • NC 005
  • NSC 2150
CAS:
148-53-8
MF:
C8H8O3
MW:
152.15
EINECS:
205-715-3
Product Categories:
  • Aromatics
  • Aldehydes
  • Building Blocks
  • C8
  • Carbonyl Compounds
  • Chemical Synthesis
  • Aromatic Aldehydes & Derivatives (substituted)
  • Organic Building Blocks
  • bc0001
Mol File:
148-53-8.mol
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3-Methoxysalicylaldehyde Chemical Properties

Melting point:
40-42 °C (lit.)
Boiling point:
265-266 °C (lit.)
Density 
1.2143 (rough estimate)
refractive index 
1.4945 (estimate)
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
Chloroform (Sparingly), Methanol (Slightly)
form 
Low Melting Solid
pka
pK1:7.912 (25°C)
color 
Pale yellow to brown
Water Solubility 
slightly soluble
Sensitive 
Air Sensitive
BRN 
471913
Stability:
Hygroscopic
LogP
1.370
CAS DataBase Reference
148-53-8(CAS DataBase Reference)
NIST Chemistry Reference
Benzaldehyde, 2-hydroxy-3-methoxy-(148-53-8)
EPA Substance Registry System
Benzaldehyde, 2-hydroxy-3-methoxy- (148-53-8)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
23-36-24/25-36/37/39-27-26
WGK Germany 
3
RTECS 
CU6530000
10-23
TSCA 
Yes
HS Code 
29124900

MSDS

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3-Methoxysalicylaldehyde Usage And Synthesis

Chemical Properties

Pale yellow to brown low melting solid

Uses

o-Vanillin has been used to study the solvent-free reaction between o-vanillin and p-toluidine using NMR, DSC and XRD analysis. It was used in the synthesis of new ligand for Fe(III) and Al(lII). It is also used in the study of mutagenesis and as a synthetic precursor for pharmaceuticals.

Uses

o-Vanillin has been used to study the solvent-free reaction between o-vanillin and p-toluidine using NMR, DSC and XRD analysis. It was used in the synthesis of new ligand for Fe(III) and Al(lII).

Uses

A positional isomer of Vanillin. o-Vanillin is a more potent antioxidant than Vanillin.

Definition

ChEBI: A member of the class of benzaldehydes that is salicylaldehyde substituted by a methoxy group at position 3.

Hazard

ortho-Vanillin is harmful if ingested, irritating to eyes, skin and respiratory system, but has an unmistakable high LD50 of 1330 mg/kg in mice.

Biochem/physiol Actions

o-Vanillin induces DNA damage as detected by comet assay.

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