3-Fluorophenylhydrazine hydrochloride Chemical Properties

Melting point:

268 °C (dec.)(lit.)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform : DMSO = 1 : 1 (Slightly), Methanol (Slightly)

form 

Powder

color 

White to light brown

BRN 

3627729

InChI

InChI=1S/C6H7FN2.ClH/c7-5-2-1-3-6(4-5)9-8;/h1-4,9H,8H2;1H

InChIKey

SKVGLOFWEJFQKU-UHFFFAOYSA-N

SMILES

C1(NN)=CC=CC(F)=C1.Cl

CAS DataBase Reference

2924-16-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi,T

Risk Statements 

20/21/22-36/37/38-43-40-23/24/25

Safety Statements 

26-37/39-45-36/37-36

RIDADR 

2811

WGK Germany 

3

HazardClass 

IRRITANT

PackingGroup 

III

HS Code 

29280000

MSDS

• Language:English Provider:1-(3-Fluorophenyl)hydrazine hydrochloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3-Fluorophenylhydrazine hydrochloride Usage And Synthesis

Chemical Properties

white to light yellow crystal powde

Uses

3-Fluorophenylhydrazine Hydrochloride can be used to synthesize compounds that are useful for the prophylaxis and treatment of pro-inflammatory cytokine mediated diseases, and in particular, p38 activity mediated inflammation and related conditions.

Synthesis

4) Saltation reaction: 22.1 g of (3-fluorophenyl)hydrazine was dissolved in 15.4 mL of 37% hydrochloric acid and stirred at 65 °C until crystals precipitated from the reaction solution. The reaction solution was then cooled to 20 °C and the solid product was collected by filtration. The filter cake was washed with acetone and dried to give 24.4 g of 3-fluorophenylhydrazine hydrochloride with 99.2% purity and 39.1% yield.

References

[1] Patent: CN106518716, 2017, A. Location in patent: Paragraph 0026

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