HARMALOL HYDROCHLORIDE DIHYDRATE Chemical Properties

Melting point:

265-268 °C (dec.)

storage temp. 

Refrigerator (+4°C)

solubility 

DMF:10.0(Max Conc. mg/mL);36.67(Max Conc. mM)
DMSO:1.0(Max Conc. mg/mL);3.67(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);7.33(Max Conc. mM)

form 

A solid

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29339980

MSDS

• Language:English Provider:SigmaAldrich

HARMALOL HYDROCHLORIDE DIHYDRATE Usage And Synthesis

Description

Harmalol is a β-carboline alkaloid and an active metabolite of harmaline that has been found in P. harmala and has diverse biological activities.1,2,3,4,5 It is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A; IC50 = 0.63 µM) and monoamine oxidase A (MAO-A; IC50 = 0.66 µM).3 It is selective for DYRK1A over Cdk1, Cdk5, CK1α1, Clk4, DYRK2, Pim-1, and GSK3β but also inhibits DYRK1B and Clk1 at 10 µM. It inhibits proliferation of H4 human glioblastoma cells (IC50s = 23.7 µM). Harmalol (0.5-12.5 µM) reduces increases in the levels of the cytochrome P450 (CYP) isoform CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells and prevents TCDD-induced activation of the aryl hydrocarbon receptor (AhR) in guinea pig hepatic cytosolic extracts.4 It reduces glutamate-induced cytotoxicity, cytochrome c release, caspase-3 activation, and the production of reactive oxygen species (ROS) in PC12 cells when used at a concentration of 25 µM.5 This product is also available as an analytical reference standard (Item No. 35145).WARNING This product is not for human or veterinary use.

Chemical Properties

yellow crystalline powder

HARMALOL HYDROCHLORIDE DIHYDRATE(6028-00-8)Related Product Information

• HARMALOL
• harmaline hydrochloride
• HARMALINE HYDROCHLORIDE DIHYDRATE
• HARMALOL HYDROCHLORIDE DIHYDRATE