5-Bromo-1,3-benzenedicarbonitrile Chemical Properties

Boiling point:

257 °C

Density 

1.68

Flash point:

109 °C

storage temp. 

Sealed in dry,Room Temperature

Appearance

White to yellow Solid

5-Bromo-1,3-benzenedicarbonitrile Usage And Synthesis

Uses

5-Bromo-1,3-benzenedinitrile is mainly used as an intermediate in organic synthesis, especially in pharmaceutical and pesticide chemistry.

Synthesis

The general procedure for the synthesis of 5-bromoisophthalonitrile from the compound (CAS: 820231-67-2): Intermediate C (34.5 g, 97.1 mmol) and thionyl chloride (250 g) were added to a round-bottomed flask, and the reaction mixture was heated and refluxed for about 1.5 hours. Upon completion of the reaction, the excess thionyl chloride was removed by distillation. Subsequently, the yellow solid obtained was purified using silica gel column chromatography (eluent: toluene). Finally, the solvent was removed from the purified mixture by reduced pressure distillation to afford 14.7 g of Intermediate D as white crystals (yield: 73.1%).

References

[1] Patent: EP1640365, 2006, A1. Location in patent: Page/Page column 65

5-Bromo-1,3-benzenedicarbonitrile(160892-07-9)Related Product Information

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• 3-BROMO-5-METHYLBENZONITRILE