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4-(Aminomethyl)benzoic acid

Basic information Description References Safety Supplier Related

4-(Aminomethyl)benzoic acid Basic information

Product Name:
4-(Aminomethyl)benzoic acid
Synonyms:
  • AMINOMETHYL BENZOIC ACID
  • H-4-AMB-OH
  • H-(4)AMBZ-OH
  • LABOTEST-BB LT00053184
  • 4-CARBOXYBENZYLAMINE
  • 4-(AMINOMETHYL)BENZOIC ACID
  • RARECHEM AL BW 0005
  • NH2-CH2-PH(4)-COOH
CAS:
56-91-7
MF:
C8H9NO2
MW:
151.16
EINECS:
200-297-9
Product Categories:
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Aromatic Amino Acids
  • CARBOXYLICACID
  • Pharmaceutical Raw Materials
  • Peptide Synthesis
  • Unnatural Amino Acid Derivatives
  • Acids and Derivatives
  • Amines and Anilines
  • 56-91-7
Mol File:
56-91-7.mol
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4-(Aminomethyl)benzoic acid Chemical Properties

Melting point:
≥300 °C (lit.)
Boiling point:
273.17°C (rough estimate)
Density 
1.2023 (rough estimate)
refractive index 
1.5810 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Aqueous Base (Slightly), Water (Slightly, Heated, Sonicated)
pka
3.75±0.10(Predicted)
form 
Powder
color 
White to almost white
Water Solubility 
Slightly soluble in water. Insoluble in ethanol, benzene and chloroform.
BRN 
1100606
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
QCTBMLYLENLHLA-UHFFFAOYSA-N
CAS DataBase Reference
56-91-7(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39-26,37/39
WGK Germany 
3
HS Code 
29224999

MSDS

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4-(Aminomethyl)benzoic acid Usage And Synthesis

Description

4-(Aminomethyl)benzoic acid is a organic compound that can serve as a type 2 antifibrinolytic agent used in the treatment of fibrotic skin disorders, such as Peyronie's disease. It is believed that 4-(Aminomethyl)benzoic acid is effective to increase the oxygen uptake at the tissue level and enhance activity of monoamine oxidase, thus to promote the degradation of serotonin, which in excess, may lead to fibrotic changes. It is also administrated by mouth to treat several skin conditions including vitiligo, pemphigus, dermatomyositis, morphea, lymphoblastoma cutis and scleroderma. It is sometimes used in pill form by patients suffering from irritable bowel syndrome to treat the relevant gastrointestinal symptoms and applied in nutritional epidemiological studies to assess the completeness of 24-hour urine collection for the determination of urinary sodium, potassium, or nitrogen levels. Besides, it can also serve as nutritional supplements to darken gray hair, prevent hair loss, make skin look younger and prevent sunburn and its benefits are claimed for people with fatigue, irritability, depression, weeping eczema, scleroderma, patchy pigment loss in skin, and premature grey hair.

References

https://en.wikipedia.org/wiki/4-Aminobenzoic_acid
https://www.alfa.com/en/catalog/B23519/
https://pubchem.ncbi.nlm.nih.gov/compound/4-aminobenzoic_acid#section=Top
http://www.webmd.com/vitamins-supplements/ingredientmono-1004-PABA+PARA-AMINOBENZOIC+ACID+PABA.aspxactiveIngredientId=1004&activeIngredientName=PABA

Chemical Properties

white to light yellow crystal powde

Uses

4-(Aminomethyl)benzoic acid acts as an unnatural amino acid derivative. It is also used as a type 2 antifibrinolytic agent. Further, it reacts with 2-methyl-isothiourea sulfate to prepare 4-guanidinomethylbenzoic acid.

Uses

4-(Aminomethyl)benzoic acid (PAMBA) can be used in the synthesis of:

  • Cobalt carboxy phosphonates.
  • Apoptozole (Az), which has cellular potency to promote membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel activity.
  • Cyclopeptide composed of L-glutamic acid and 3-aminobenzoic acid that can be used as receptors for a variety of cations and anions.
  • A bioactive peptide which has potent GPR54 (a G protein-coupled receptor) agonistic activity.

Uses

4-(Aminomethyl)benzoic Acid is a type 2 antifibrinolytic agent.

Definition

ChEBI: Aminomethylbenzoic acid is a member of benzoic acids.

4-(Aminomethyl)benzoic acid Preparation Products And Raw materials

Preparation Products

Raw materials

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