trans-Chalcone Chemical Properties

Melting point:

55-59 °C

Boiling point:

208 °C25 mm Hg(lit.)

Density 

1.0712

refractive index 

1.5361 (estimate)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly)

form 

Solid

color 

Pale Yellow

Odor

at 100.00 %. floral balsam herbal

Odor Type

floral

Water Solubility 

Soluble in chloroform, ether, benzene, and ethanol (slightly). Insoluble in water.

Merck 

14,2037

BRN 

509985

LogP

4.013 (est)

CAS DataBase Reference

614-47-1(CAS DataBase Reference)

NIST Chemistry Reference

Benzalacetophenone(614-47-1)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37

Safety Statements 

22-36/37/39-45

WGK Germany 

3

RTECS 

UD5576750

HS Code 

29143990

MSDS

• Language:English Provider:1,3-Diphenyl-2-propen-1-one
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

trans-Chalcone Usage And Synthesis

Description

trans-Chalcone is an open chain flavonoid that may prevent lung and forestomach cancer.

Chemical Properties

Trans-Chalcone is a yellowish crystals. M.P. 58℃. (trans-isomer). M .P. 46℃. (cis-isomer).Sp.Gr. 1.07 (liquid).Insoluble in water, soluble in alcohol (poorly) and oils.

Uses

trans-Chalcone is a positive allosteric modulator of α7 nicotinic acetylcholine receptors and exhibits antioxidant activity.

Definition

ChEBI: Chalcone is a member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene group. It has a role as a plant metabolite. It is a member of styrenes and a member of chalcones.

Application

trans-Chalcone was used in the synthesis of cis and trans diphenyl cyclopropane. It was also used in screening of surface adsorbed species of isobutybenzene and 4-isobutylacetophenone on bulk fosfotungstic Wells-Dawson acid (H6P2W18O62.xH2O).

Preparation

trans-Chalcones have been obtained in good yields and selectivities following an environmentally friendly methodology by using montmorillonite KSF as a reusable heterogeneous catalyst.
Clay-catalysed solventless synthesis of trans-chalcones

Synthesis Reference(s)

Journal of the American Chemical Society, 104, p. 4724, 1982 DOI: 10.1021/ja00381a058

General Description

trans-Chalcone is an open chain flavonoid that may prevent lung and forestomach cancer.

Biological Activity

trans-Chalcone exhibits antifungal activity against Trichophyton rubrum. It is inhibitor of fatty acid synthase and α-amylase. It induces programmed cell death due to reduced mitochondrial transmembrane potential in Arabidopsis thaliana roots.

Biochem/physiol Actions

trans-Chalcone exhibits antifungal activity against Trichophyton rubrum. It is inhibitor of fatty acid synthase and α-amylase. It induces programmed cell death due to reduced mitochondrial transmembrane potential in Arabidopsis thaliana roots.

Synthesis

Trans-Chalcone is synthesized by condensation of Benzaldehyde with Acetophenone.

trans-Chalcone(614-47-1)Related Product Information

• PROPYLENE
• tert-Butylchlorodiphenylsilane
• trans,trans-2,4-Undecadienal
• 1,3-Diphenyl-2-thiourea
• DIPHENYLCYCLOPROPENONE
• Dichlorodiphenylsilane
• Diphenylphosphine
• Biphenyl
• Diphenylsilane
• Diphenylmethane
• Chlorodiphenylphosphine
• Neosperidin dihydrochalcone
• 3-HYDROXYFLAVONE
• Galangin
• 7,8-Dihydroxyflavone
• α-Naphthoflavone
• 4'-METHOXYCHALCONE
• Apigenin