2-Picoline-N-oxide Chemical Properties

Melting point:

41-45 °C(lit.)

Boiling point:

259-261 °C

Density 

1.1143 (rough estimate)

refractive index 

1.5444 (estimate)

Flash point:

>230 °F

pka

pK1:1.029(+1) (25°C)

form 

powder to lump to clear liquid

color 

White or Colorless to Light yellow

Water Solubility 

soluble

Sensitive 

Hygroscopic

BRN 

106916

CAS DataBase Reference

931-19-1(CAS DataBase Reference)

NIST Chemistry Reference

Pyridine, 2-methyl-, 1-oxide(931-19-1)

EPA Substance Registry System

2-Methylpyridine-1-oxide (931-19-1)

Safety Information

Hazard Codes 

Xi,Xn,F

Risk Statements 

36/37/38-20/21/22-10

Safety Statements 

26-36-24/25-16

WGK Germany 

3

F 

3

TSCA 

Yes

HS Code 

29333990

MSDS

• Language:English Provider:2-Picoline-N-oxide
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2-Picoline-N-oxide Usage And Synthesis

Chemical Properties

light yellow to brown crystalline low melting mass

Uses

2-Picoline N-oxide is used in proteomics research. Also used as pharmaceutical intermediates.

Application

2-Methylpyridine 1-oxide is a useful building block for organic synthesis.

Definition

ChEBI: Picoline N-oxide is a member of methylpyridines and a member of pyridine N-oxides.

Purification Methods

Purify the N-oxide by fractional distillation, and it can be recrystallised from *C6H6/hexane but is hygroscopic. [Bullitt & Maynard J Am Chem Soc 76 1370 1954, Ross et al. J Am Chem Soc 78 3625 1956, IR: Wiley & SlaymAker J Am Chem Soc 79 2233 1957.] The picrate has m 125-126.5o (from EtOH) [Boekelheide & Linn J Am Chem Soc 76 1286 1954]. The phthalate has m 115-116o (from EtOH) [den Hertog et al. Recl Trav Chim Pays-Bas 70 591 1951.]. [Beilstein 20 III/IV 2689, 20/5 V 479.]

2-Picoline-N-oxide(931-19-1)Related Product Information

• 2,6-Lutidine
• 2,4,6-Collidine
• Pyridine-N-oxide
• Azamethiphos
• Magnesium oxide
• Iron oxide
• Iron oxide black
• Zinc oxide
• 2,2,6,6-Tetramethylpiperidinooxy
• NITRIC OXIDE
• 2-Chloro-5-chloromethylpyridine
• 2-Picoline
• Rutile
• Chromium picolinate
• 4-Methylpyridine
• ETHYLENE OXIDE
• (Diethoxymethyl)diphenylphosphine oxide
• 7-CHLORO-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPINE-2-ONE-4-OXIDE