MERANZIN Chemical Properties

Melting point:

89-92 °C(Solv: ethyl ether (60-29-7))

Boiling point:

414.8±45.0 °C(Predicted)

Density 

1.223±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Cryst.

color 

White to off-white

optical activity

[α]/D -48.0 to -44.0° in chloroform (0.063 g/100 mL)

InChI

InChI=1S/C15H16O4/c1-15(2)12(19-15)8-10-11(17-3)6-4-9-5-7-13(16)18-14(9)10/h4-7,12H,8H2,1-3H3/t12-/m0/s1

InChIKey

LSZONYLDFHGRDP-LBPRGKRZSA-N

SMILES

C1(=O)OC2=C(C[C@H]3C(C)(C)O3)C(OC)=CC=C2C=C1

LogP

1.920 (est)

MERANZIN Usage And Synthesis

Uses

Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression[1][2].

target

Immunology & Inflammation related

References

[1] Lan Li, et al. Chaihu-Shugan-San and Absorbed Meranzin Hydrate Induce Anti-Atherosclerosis and Behavioral Improvements in High-Fat Diet ApoE -/- Mice via Anti-Inflammatory and BDNF-TrkB Pathway. Biomed Pharmacother. 2019 Jul;115:108893. DOI:10.1016/j.biopha.2019.108893
[2] Rongwei Yan, et al. Preparative Isolation and Purification of Hainanmurpanin, Meranzin, and Phebalosin From Leaves of Murraya Exotica L. Using Supercritical Fluid Extraction Combined With Consecutive High-Speed Countercurrent Chromatography. J Sep Sci. 20 DOI:10.1002/jssc.201701423

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