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Irsogladine

Basic information Safety Supplier Related

Irsogladine Basic information

Product Name:
Irsogladine
Synonyms:
  • 5-triazine-2,4-diamine,6-(2,5-dichlorophenyl)-3
  • 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine
  • 2,4-diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine
  • Irsogladin
  • Irsogladine,2,4-DiaMino-6-(2,5-dichlorophenyl)-1,3,5-triazine
  • IRSOGLADINE
  • Irsogladine free base
  • 2',5'-Dichlorobenzoguanamine
CAS:
57381-26-7
MF:
C9H7Cl2N5
MW:
256.09
Product Categories:
  • Active Pharmaceutical Ingredients
  • pharmaceutical intermediates
  • Inhibitors
Mol File:
57381-26-7.mol
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Irsogladine Chemical Properties

Melting point:
268-269°C
Boiling point:
552.2±60.0 °C(Predicted)
Density 
1.572
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
insoluble in H2O; insoluble in EtOH; ≥12.80 mg/mL in DMSO
form 
solid
pka
3.88±0.10(Predicted)
color 
White to off-white
CAS DataBase Reference
57381-26-7(CAS DataBase Reference)
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Irsogladine Usage And Synthesis

Definition

ChEBI: 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine is a dichlorobenzene.

Biological Activity

irsogladine is a pde4 inhibitor and muscarinic acetylcholine receptor binder.irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (p < 0.02, p < 0.001), in tpa-deficient mic

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