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ECHINACOSIDE

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ECHINACOSIDE Basic information

Product Name:
ECHINACOSIDE
Synonyms:
  • (1-3)-o-(beta-d-glucopyranosyl-(1-6))-,4-(3-(3,4-dihydroxyphenyl)-2-propenoat
  • 2-(3,4-dihydroxyphenyl)ethylo-6-deoxy-alpha-l-mannopyranosyl-glucopyranosid
  • beta-d-e
  • ECHINACOSIDE
  • ECHINACOSIDE(AMERICAN HERBAL PHARMACOPOEIA)
  • ECHINACOSIDE 20% DESERTLIVING CISTANCHE P.E.
  • Cistanche tubulosa
  • Echinacoside/CH80711
CAS:
82854-37-3
MF:
C35H46O20
MW:
786.73
EINECS:
240-851-7
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Sugars, Carbohydrates & Glucosides
Mol File:
82854-37-3.mol
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ECHINACOSIDE Chemical Properties

Boiling point:
1062.7±65.0 °C(Predicted)
Density 
1.66±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO:60.0(Max Conc. mg/mL);76.26(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.13(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);38.13(Max Conc. mM)
Ethanol:52.5(Max Conc. mg/mL);66.73(Max Conc. mM)
Water:24.36(Max Conc. mg/mL);30.96(Max Conc. mM)
form 
powder
pka
8.43±0.20(Predicted)
color 
White-beige
BRN 
4778612
Stability:
Hygroscopic
InChIKey
FSBUXLDOLNLABB-ISAKITKMSA-N
LogP
0.140 (est)
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Safety Information

Safety Statements 
24/25
WGK Germany 
3
RTECS 
LZ5786500
HS Code 
29389090
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ECHINACOSIDE Usage And Synthesis

Description

Echinacoside is a phenylethanoid glycoside that has been found in Echinacea and has diverse biological activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals (EC50 = 6.6 μM in a cell-free assay). Echinacoside (10 μg/ml) inhibits hydrogen peroxide-induced production of reactive oxygen species (ROS) and apoptosis in PC12 cells. It reduces increases in plasma alanine aminotransferase (ALT), TNF-α, IL-1β, IL-16, and IL-10 levels and hepatocyte apoptosis induced by LPS/D-galactosamine in a mouse model of acute liver injury when administered at a dose of 60 mg/kg. Echinacoside (20 mg/kg per day for 15 days) prevents loss of dopaminergic neurons in the substantia nigra pars compacta and decreases in striatal dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) levels in a mouse model of MPTP-induced Parkinson''s disease. It also improves motor performance in the rotarod test in the same model.

Chemical Properties

White powder

Uses

Echinacoside Ethanolate is a caffeic acid glycoside, known for its neuroprotective, antiinflammatory and anti-oxidative activities. Also an anti[proliferative towards hypoxia influenced pulmonary artery smooth muscle cells.

Definition

ChEBI: Echinacoside is an oligosaccharide.

in vivo

Echinacoside (30-270 mg/kg body weight; p.o.; daily for 12 weeks) significantly reverses the increases of body weight, serum hydroxyproline (HOP) levels, and the decreases of uterus wet weight and bone mineral density (BMD) in In ovariectomized (OVX) rats[3].

Animal Model:Fifty-six aged 6 months female Sprague-Dawley rats (OVX rat model)[3]
Dosage:30, 90, 270 mg/kg body weight
Administration:p.o.; daily for 12 weeks
Result:The increases of body weight, serum hydroxyproline (HOP) levels, and the decreases of uterus wet weight and BMD were significantly reversed.

ECHINACOSIDESupplier

Wuhan ChemFaces Biochemical Co., Ltd. Gold
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18607101326 15172504745
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aileen@chemfaces.com
Chengdu Peter-like Biotechnology Co., Ltd. Gold
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028-81700200 18108052721
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2850505130@qq.com
Chengdu Push Bio-Technology Co., Ltd. Gold
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028-85370565-229 18080489829
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3004654993@qq.com
Nanjing bingcheng Biotechnology Co., Ltd. Gold
Tel
18805194892
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2727751293@qq.com
J & K SCIENTIFIC LTD.
Tel
18210857532
Email
jkinfo@jkchemical.com
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