ECHINACOSIDE Chemical Properties

Boiling point:

1062.7±65.0 °C(Predicted)

Density 

1.66±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,2-8°C

solubility 

DMSO:60.0(Max Conc. mg/mL);76.26(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.13(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);38.13(Max Conc. mM)
Ethanol:52.5(Max Conc. mg/mL);66.73(Max Conc. mM)
Water:24.36(Max Conc. mg/mL);30.96(Max Conc. mM)

form 

powder

pka

8.43±0.20(Predicted)

color 

White-beige

BRN 

4778612

Stability:

Hygroscopic

InChIKey

FSBUXLDOLNLABB-ISAKITKMSA-N

LogP

0.140 (est)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

RTECS 

LZ5786500

HS Code 

29389090

ECHINACOSIDE Usage And Synthesis

Description

Echinacoside is a phenylethanoid glycoside that has been found in Echinacea and has diverse biological activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals (EC₅₀ = 6.6 μM in a cell-free assay). Echinacoside (10 μg/ml) inhibits hydrogen peroxide-induced production of reactive oxygen species (ROS) and apoptosis in PC12 cells. It reduces increases in plasma alanine aminotransferase (ALT), TNF-α, IL-1β, IL-16, and IL-10 levels and hepatocyte apoptosis induced by LPS/D-galactosamine in a mouse model of acute liver injury when administered at a dose of 60 mg/kg. Echinacoside (20 mg/kg per day for 15 days) prevents loss of dopaminergic neurons in the substantia nigra pars compacta and decreases in striatal dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) levels in a mouse model of MPTP-induced Parkinson''s disease. It also improves motor performance in the rotarod test in the same model.

Chemical Properties

White powder

Uses

Echinacoside Ethanolate is a caffeic acid glycoside, known for its neuroprotective, antiinflammatory and anti-oxidative activities. Also an anti[proliferative towards hypoxia influenced pulmonary artery smooth muscle cells.

Definition

ChEBI: Echinacoside is an oligosaccharide.

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