Mal-?PEG4-?propargyl
Mal-?PEG4-?propargyl Basic information
- Product Name:
- Mal-?PEG4-?propargyl
- Synonyms:
-
- Mal-?PEG4-?propargyl
- Propargyl-PEG4-Mal
- 1H-Pyrrole-2,5-dione, 1-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)-
- 1-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethyl]pyrrole-2,5-dione
- 1-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
- 1-(3,6,9,12-Tetraoxapentadec-14-yn-1-yl)-1H-pyrrole-2,5-dione
- CAS:
- 1262681-30-0
- MF:
- C15H21NO6
- MW:
- 311.33
- Mol File:
- 1262681-30-0.mol
Mal-?PEG4-?propargyl Chemical Properties
- Boiling point:
- 432.0±40.0 °C(Predicted)
- Density
- 1.190±0.06 g/cm3(Predicted)
- solubility
- good in water, DMF, DMSO
- form
- Oil
- pka
- -2.34±0.20(Predicted)
- color
- Colorless to light yellow
- Appearance
- yellow oil
Mal-?PEG4-?propargyl Usage And Synthesis
Description
Propargyl-PEG4-Maleimide has a propargyl group and a maleimide group. The propargyl group reacts with azide compounds or biomolecules under the catalyzation of copper in Click Chemistry reactions. The maleimide group enables the formation of a covalent bond with biomolecules containing a thiol group.
Uses
Mal-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Mal-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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