N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3
N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 Basic information
- Product Name:
- N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3
- Synonyms:
-
- N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3
- 2-(3-(5-((2,5,8,11-Tetraoxatridecan-13-yl)oxy)-1,3,3-trimethylindolin-2-ylidene)prop-1-en-1-yl)-5-((3,6,9,12-tetraoxapentadec-14-yn-1-yl)oxy)-1,3,3-trimethyl-3H-indol-1-ium chloride
- CAS:
- 2107273-62-9
- MF:
- C45H65ClN2O10
- MW:
- 829.47
- Mol File:
- 2107273-62-9.mol
N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 Chemical Properties
- solubility
- Soluble in Water, DMSO, DMF, DCM
N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 Usage And Synthesis
Description
N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 is a PEG linker containing cyanine dye with excitation/emmission maximum 555/570 nm and an alkyne group, which enables copper-catalyzed Click Chemistry. The hydophilic PEG spacer increases solubility in aqueous media.
Uses
N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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