Basic information Safety Supplier Related

Pomalidomide-PEG4-azide

Basic information Safety Supplier Related

Pomalidomide-PEG4-azide Basic information

Product Name:
Pomalidomide-PEG4-azide
Synonyms:
  • Pomalidomide-PEG4-azide
  • Pomalidomide-NH-?PEG4-?azide
  • 4-((14-azido-3,6,9,12-tetraoxatetradecyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
  • 14-Azido-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12-tetraoxatetradecanamide, Crosslinker-E3 ligase ligand conjugate, Pomalidomide conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
  • Pomalidomide-PEG?-Azide
  • 1H-Isoindole-1,3(2H)-dione, 4-[(14-azido-3,6,9,12-tetraoxatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)-
CAS:
2271036-47-4
MF:
C23H30N6O8
MW:
518.53
Mol File:
2271036-47-4.mol
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Pomalidomide-PEG4-azide Chemical Properties

storage temp. 
2-8°C
form 
Oil
color 
Light yellow to green yellow
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Pomalidomide-PEG4-azide Usage And Synthesis

Uses

Protein degrader builiding block Pomalidomide-PEG4-Azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

storage

Store at -20°C

Pomalidomide-PEG4-azideSupplier

Shanghai Aladdin Bio-Chem Technology Co.,LTD
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400-400-6206333 18521732826
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market@aladdin-e.com
Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 18892239720
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psaitong@jm-bio.com
Xi'an Confluore Biological Technology Co., Ltd.
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+86-156-80926068 +86-15680926068
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1924344760@qq.com
Jilin Province Woda Biotechnology Co., Ltd.
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13504435624
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1927928688@qq.com