Thalidomide-O-PEG4-amine Chemical Properties

Boiling point:

690.9±55.0 °C(Predicted)

Density 

1.321±0.06 g/cm3(Predicted)

pka

10.70±0.40(Predicted)

Safety Information

HS Code 

2933998090

Thalidomide-O-PEG4-amine Usage And Synthesis

Description

Thalidomide-O-PEG4-Amine is synthesized compound that can react with NHS ester group or carboxylic acid in the presence of EDC or HATU

Uses

Thalidomide-O-PEG4-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

IC 50

Cereblon

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Thalidomide-O-PEG4-amine(2401832-00-4)Related Product Information

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• Thalidomide-O-PEG4-Boc
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• Thalidomide-O-PEG3-amine HCl
• Acetamide, N-[2-[3-[3-(2-aminoethoxy)propoxy]propoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
• Thalidomide-O-PEG4-azide