Basic information Safety Supplier Related

Pomalidomide-PEG2-N3

Basic information Safety Supplier Related

Pomalidomide-PEG2-N3 Basic information

Product Name:
Pomalidomide-PEG2-N3
Synonyms:
  • Pomalidomide-PEG2-N3
  • Pomalidomide-NH-CO-PEG2-N3
  • 2-(2-(2-Azidoethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide, Crosslinker?E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
  • N3-PEG2-CH2CO-Poma
  • Acetamide, 2-[2-(2-azidoethoxy)ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-
  • 2-(2-(2-Azidoethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide?, Pomalidomide-PEG2-azide
CAS:
2267306-14-7
MF:
C19H20N6O7
MW:
444.4
Mol File:
2267306-14-7.mol
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Pomalidomide-PEG2-N3 Chemical Properties

Melting point:
188 °C
storage temp. 
2-8°C
solubility 
DMSO: 90 mg/mL (202.52 mM)
form 
Solid
color 
Off-white to light yellow
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Pomalidomide-PEG2-N3 Usage And Synthesis

Uses

Protein degrader builiding block Pomalidomide-PEG2-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Pomalidomide-PEG2-N3Supplier

Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 18892239720
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psaitong@jm-bio.com
Xi'an Confluore Biological Technology Co., Ltd.
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+86-156-80926068 +86-15680926068
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1924344760@qq.com
Jiangsu aikang biomedical research and development co., LTD
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025-66110311 13155353615
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qzhang@aikonchem.com
Jilin Province Woda Biotechnology Co., Ltd.
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Shanghai Kaiwei Chemical Technology Co., Ltd.
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