Pomalidomide-PEG2-N3 Chemical Properties

Melting point:

188 °C

storage temp. 

2-8°C

solubility 

DMSO: 90 mg/mL (202.52 mM)

form 

Solid

color 

Off-white to light yellow

Pomalidomide-PEG2-N3 Usage And Synthesis

Uses

Protein degrader builiding block Pomalidomide-PEG2-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

reaction suitability

reaction type: click chemistry
reagent type: ligand-linker conjugate

IC 50

Cereblon

Pomalidomide-PEG2-N3(2267306-14-7)Related Product Information

• Pomalidomide-PEG1-azide
• Pomalidomide-PEG3-N3
• E3 ligase Ligand-Linker Conjugates 50
• Pomalidomide-PEG3-CO2H
• Pomalidomide-PEG4-azide
• E3 Ligase Ligand-Linker Conjugates 22
• 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
• Pomalidomide-PEG4-CO2H
• E3 Ligase Ligand-Linker Conjugates 1
• POMALIDOMIDE-PEG2-CO2H
• Pomalidomide-PEG5-CO2H
• POMALIDOMIDE-PEG1-CO2H
• Pomalidomide-O-C4-NH2
• Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]-
• Pomalidomide-PEG6-butyl iodide
• Pomalidomide-PEG2-butyl iodide
• Pomalidomide-NH-CO-PEG6-N3
• Pomalidomide-PEG5-N3