Thalidomide-O-PEG4-Propargyl Chemical Properties

Boiling point:

673.9±55.0 °C(Predicted)

Density 

1.320±0.06 g/cm3(Predicted)

storage temp. 

-20°C, stored under nitrogen

solubility 

Soluble in Water, DMF, DCM, DMSO

pka

10.70±0.40(Predicted)

form 

Solid

color 

White to light yellow

Safety Information

HS Code 

2933998090

Thalidomide-O-PEG4-Propargyl Usage And Synthesis

Description

Thalidomide-O-PEG4-Propargyl is synthesized compound that incorporates the Thalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology, Propargyl is reactive with azide molecule in the presence of Cu catalyst.

Uses

Thalidomide-PEG4-Propargyl is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Thalidomide-PEG4-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

Cereblon

References

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-998. DOI:10.1016/j.str.2020.07.015

Thalidomide-O-PEG4-Propargyl(2098799-77-8)Related Product Information

• 1H-Isoindole-1,3(2H)-dione, 4-[2-(2-aminoethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)-
• Cereblon Ligand 1
• E3 Ligase Ligand-Linker Conjugates 21
• E3 Ligase Ligand-Linker Conjugates 19
• Thalidomide-linker 10
• Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl-
• Thalidomide-O-amido-C4-NH2 hydrochloride
• Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride
• Thalidomide-O-amido-C8-NH2 hydrochloride
• Thalidomide-O-PEG4-Boc
• tert-butyl 3,3'-(2-aMino-2-((3-tert-butoxy-3-oxopropoxy)Methyl)propane-1,3-diyl)bis(oxy)dipropanoate
• Thalidomide-linker 13
• E3 Ligase Ligand-Linker Conjugates 20