ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > TGF-beta / Smad > TGF-beta / Smad inhibitors > SD-208
SD-208
SD-208 Basic information
- Product Name:
- SD-208
- Synonyms:
-
- SD-208
- 2-[(5-CHLORO-2-FLUOROPHENYL)PTERIDIN-4-YL]PYRIDIN-4-YL-AMINE
- 2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine
- 2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine
- CS-2295
- SD-208 (SD 208
- SD 208;SD208;TGF-Β RI KINASE INHIBITOR V
- 4-PteridinaMine, 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-
- CAS:
- 627536-09-8
- MF:
- C17H10ClFN6
- MW:
- 352.75
- Product Categories:
-
- Inhibitors
- Smad
- TGF-beta
- Mol File:
- 627536-09-8.mol
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SD-208 Chemical Properties
- Boiling point:
- 460.4±45.0 °C(Predicted)
- Density
- 1.487
- storage temp.
- 2-8°C
- solubility
- DMSO: >5mg/mL
- form
- powder
- pka
- 4.56±0.26(Predicted)
- color
- off-white to tan
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SD-208 Usage And Synthesis
Uses
SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.2
Biological Activity
Potent, orally active ATP-competitive transforming growth factor- β receptor 1 (TGF- β RI) inhibitor (IC 50 = 49nM). Displays > 100-fold and > 17-fold selectivity over TGF- β RII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity.
Biochem/physiol Actions
SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.1
storage
Store at RT
SD-208Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
BeiJing Hwrk Chemicals Limted
- Tel
- 0757-86329057 18934348241
- sales4.gd@hwrkchemical.com
Shanghai Ennopharm Co., Ltd.
- Tel
- +86 (21) 6435-5022
Nanjing JinruiJiuAn Biotechnology Co., Ltd.
- Tel
- 025-58196018 800028039
- sales@fartop.net