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SD-208

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SD-208 Basic information

Product Name:
SD-208
Synonyms:
  • SD-208
  • 2-[(5-CHLORO-2-FLUOROPHENYL)PTERIDIN-4-YL]PYRIDIN-4-YL-AMINE
  • 2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine
  • 2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine
  • CS-2295
  • SD-208 (SD 208
  • SD 208;SD208;TGF-Β RI KINASE INHIBITOR V
  • 4-PteridinaMine, 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-
CAS:
627536-09-8
MF:
C17H10ClFN6
MW:
352.75
Product Categories:
  • Inhibitors
  • Smad
  • TGF-beta
Mol File:
627536-09-8.mol
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SD-208 Chemical Properties

Boiling point:
460.4±45.0 °C(Predicted)
Density 
1.487
storage temp. 
2-8°C
solubility 
DMSO: >5mg/mL
form 
powder
pka
4.56±0.26(Predicted)
color 
off-white to tan
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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SD-208 Usage And Synthesis

Uses

SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.2

Biological Activity

Potent, orally active ATP-competitive transforming growth factor- β receptor 1 (TGF- β RI) inhibitor (IC 50 = 49nM). Displays > 100-fold and > 17-fold selectivity over TGF- β RII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity.

Biochem/physiol Actions

SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.1

in vivo

SD-208 (1 mg/mL, p.o.) significantly prolongs the median survival of SMA-560 glioma-bearing mice[1]. In syngeneic 129S1 mice, SD-208 (60 mg/kg/d, p.o.) inhibits primary R3T tumor growth, and reduces the number and the size of lung metastases[2]. In the murine aortic allograft model, SD-208 effectively reduces the formation of intimal hyperplasia of transplant arteriosclerosis (TA)[3].

storage

Store at RT

SD-208Supplier

Shanghai Boyle Chemical Co., Ltd.
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Email
sales@boylechem.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18934348241
Email
sales4.gd@hwrkchemical.com
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Nanjing JinruiJiuAn Biotechnology Co., Ltd.
Tel
025-58196018 800028039
Email
sales@fartop.net
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SD-208(627536-09-8)Related Product Information