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A 205804

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A 205804 Basic information

Product Name:
A 205804
Synonyms:
  • A 205804
  • 4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide
  • CS-635
  • A205804;A 205804;A-205804
  • A 205804,4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxaMide
  • 4-(p-tolylthio)thieno[2,3-c]pyridine-2-carboxamide
  • Thieno[2,3-c]pyridine-2-carboxamide, 4-[(4-methylphenyl)thio]-
  • 4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide A-205804
CAS:
251992-66-2
MF:
C15H12N2OS2
MW:
300.4
Product Categories:
  • Inhibitors
Mol File:
251992-66-2.mol
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A 205804 Chemical Properties

Melting point:
198-199℃
Boiling point:
581.3±45.0 °C(Predicted)
Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
≥30 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
pka
15.12±0.30(Predicted)
form 
powder to crystal
color 
White to Orange to Green
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Safety Information

HS Code 
2934.99.9001
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A 205804 Usage And Synthesis

Description

A-205804 is a potent inhibitor of E-selectin and ICAM-1 expression in human vascular endothelial cells stimulated with TNF-α (IC50s = 20 and 25 nM, respectively). It does not block expression of VCAM-1 (IC50 > 1,000 nM).

Uses

4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide is a reagent used in the preparation of selective inhibitors of cell adhesion molecule expression in human endothelial cells.

Definition

ChEBI: 4-[(4-methylphenyl)thio]-2-thieno[2,3-c]pyridinecarboxamide is an aryl sulfide.

Biological Activity

Selective inhibitor of E-selectin and ICAM-1 expression (IC 50 values are 20, 25 and > 1000 nM for TNF- α -induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.

storage

Store at +4°C

References

[1]. stewart, a.o., et al., discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. selective inhibition of icam-1 and e-selectin expression. j med chem, 2001. 44(6): p. 988-1002.
[2]. chang, c.z., et al., valproic acid attenuates intercellular adhesion molecule-1 and e-selectin through a chemokine ligand 5 dependent mechanism and subarachnoid hemorrhage induced vasospasm in a rat model. j inflamm (lond), 2015. 12: p. 27.
[3]. zhu, g.d., et al., selective inhibition of icam-1 and e-selectin expression in human endothelial cells. 2. aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at c-2 carbamides. j med chem, 2001. 44(21): p. 3469-87.
[4]. zhu, g.d., et al., synthesis and mode of action of (125)i- and (3)h-labeled thieno[2,3-c]pyridine antagonists of cell adhesion molecule expression. j org chem, 2002. 67(3): p. 943-8.

A 205804Supplier

3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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3bsc@sina.com
Jinan Trio PharmaTech Co., Ltd.
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Dalian Meilun Biotech Co., Ltd.
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Shanghai T&W Pharmaceutical Co., Ltd.
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+86 21 61551611
TOKYO CHEMICAL INDUSTRY CO., LTD.
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03-36680489
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Sales-JP@TCIchemicals.com