DELAPRIL HCL Chemical Properties

Melting point:

166-170℃

alpha 

D22 +18.5° (c = 1 in methanol)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

DMSO:174.0(Max Conc. mg/mL);355.82(Max Conc. mM)

form 

Solid

color 

White to off-white

CAS DataBase Reference

83435-67-0(CAS DataBase Reference)

Safety Information

RTECS 

MB9668000

DELAPRIL HCL Usage And Synthesis

Description

Delapril is a new angiotensin-converting enzyme (ACE) inhibitor useful in the treatment of essential hypertension. Orally administered delapril is a prodrug which is de-esterified to its active diacid metabolite. In hypertensive patients delapril significantly decreased systolic blood pressure and ACE activity 24 hours after dosing without affecting endogeneous creatinine clearance.

Originator

Takeda (Japan)

Uses

Delapril Hydrochloride is an angiotensin-converting-enzyme inhibitor (ACE) used as an antihypertensive drug in some European and Asian countries, but not in America.

Uses

Antihypertensive; enzyme inhibitor (angiotensinconverting).

Definition

ChEBI: Delapril hydrochloride is a peptide.

brand name

Adecut

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