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4-Methoxyphenol

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4-Methoxyphenol Basic information

Product Name:
4-Methoxyphenol
Synonyms:
  • Eastman HQMME
  • ethermonomethyliqued’hydroquinone
  • Hqmme
  • Hydroquinone methyl ether
  • hydroquinonemethylether
  • Leucobasal
  • Leucodine b
  • leucodineb
CAS:
150-76-5
MF:
C7H8O2
MW:
124.14
EINECS:
205-769-8
Product Categories:
  • Liquid Crystal intermediates
  • Phenol&Thiophenol&Mercaptan
  • API intermediates
  • Biochemistry
  • Building Blocks for Liquid Crystals
  • Functional Materials
  • Phenols (Building Blocks for Liquid Crystals)
  • Reagents for Oligosaccharide Synthesis
  • Aromatic Ethers
  • organic synthesis
  • Aromatics
  • Building Blocks
  • C6 to C8
  • Chemical Synthesis
  • Organic Building Blocks
  • Oxygen Compounds
  • Phenols
Mol File:
150-76-5.mol
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4-Methoxyphenol Chemical Properties

Melting point:
56 °C
Boiling point:
243 °C(lit.)
Density 
1,55 g/cm3
vapor density 
4.3 (vs air)
vapor pressure 
<0.01 mm Hg ( 20 °C)
refractive index 
1.5286 (estimate)
Flash point:
>230 °F
storage temp. 
Refrigerator
solubility 
Soluble in acetone, ethyl acetate, ethanol, ether, benzene and carbon tetrachloride.
pka
10.21(at 25℃)
form 
Liquid
color 
Clear colorless to pale yellow
PH
5.1 (30g/l, H2O, 20℃)
Odor Threshold
0.0027ppm
Water Solubility 
40 g/L (25 ºC)
BRN 
507924
Stability:
Stable. Combustible. Incompatible with halogens, oxidizing agents.
InChIKey
NWVVVBRKAWDGAB-UHFFFAOYSA-N
CAS DataBase Reference
150-76-5(CAS DataBase Reference)
NIST Chemistry Reference
Mequinol(150-76-5)
EPA Substance Registry System
p-Methoxyphenol (150-76-5)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-36-43
Safety Statements 
24/25-26-37/39-46
WGK Germany 
1
RTECS 
SL7700000
Autoignition Temperature
789 °F
TSCA 
Yes
HS Code 
29095090
Hazardous Substances Data
150-76-5(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 1600 mg/kg

MSDS

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4-Methoxyphenol Usage And Synthesis

Chemical Properties

White crystals.

Chemical Properties

4-Methoxyphenol is a colorless to white, waxy solid with an odor of caramel and phenol. A combustible solid.

Uses

Intermediates of Liquid Crystals

Uses

Inhibitor for acrylic monomers; stabilizer for chlorinated hydrocarbons and ethyl cellulose; UV inhibitor

Uses

5HT1&2 receptor antagonist.
Mequinol (4-hydroxyanisole) is a substrate of the enzyme tyrosinase and acts as a competitive inhibitor of melanogenesis.

Indications

Mequinol (4-hydroxyanisole) is a substrate of the enzyme tyrosinase and acts as a competitive inhibitor of melanogenesis.

Synthesis Reference(s)

The Journal of Organic Chemistry, 42, p. 1479, 1977 DOI: 10.1021/jo00428a054
Synthesis, p. 751, 1983 DOI: 10.1055/s-1983-30501
Tetrahedron Letters, 34, p. 7667, 1993 DOI: 10.1016/S0040-4039(00)61534-4

General Description

Pink crystals or white waxy solid.

Air & Water Reactions

Sensitive to moisture. Water soluble.

Reactivity Profile

4-Methoxyphenol can react with oxidizing materials.

Hazard

Eye irritant and skin damage.

Health Hazard

4-Methoxyphenol is expected to cause liver and renal toxicity with narcosis, but only at high levels of exposure.

Fire Hazard

Combustible

Safety Profile

Poison by intraperitoneal route. A skin irritant. When heated to decomposition it emits acrid smoke and fumes. See also ETHERS.

Shipping

UN3335 Aviation regulated solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

Purification Methods

Crystallise 4-methoxyphenol from *benzene, pet ether or H2O, and dry it under vacuum over P2O5 at room temperature. Sublime it in vacuo. [Wolfenden et al. J Am Chem Soc 109 463 1987, Beilstein 6 IV 5717.]

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