(S)-(-)-2-Methyl-1-butanol Chemical Properties

Melting point:

-70 °C

alpha 

-5.8 º (neat 23 ºC)

Boiling point:

136-138 °C(lit.)

Density 

0.811 g/mL at 25 °C(lit.)

vapor density 

3 (vs air)

vapor pressure 

1 mm Hg ( 13.6 °C)

refractive index 

n20/D 1.409(lit.)

Flash point:

120 °F

storage temp. 

2-8°C

solubility 

soluble in Chloroform, Ethanol

form 

clear liquid

pka

15.24±0.10(Predicted)

color 

Colorless to Almost colorless

Odor

ethereal fresh

optical activity

[α]23/D 5.8°, neat

Water Solubility 

36 g/L (30 ºC)

Merck 

14,6030

BRN 

1718809

Dielectric constant

15.8（20℃）

LogP

1.223 (est)

CAS DataBase Reference

1565-80-6(CAS DataBase Reference)

NIST Chemistry Reference

1-Butanol, 2-methyl-, (S)-(1565-80-6)

EPA Substance Registry System

1-Butanol, 2-methyl-, (2S)- (1565-80-6)

Safety Information

Hazard Codes 

Xn

Risk Statements 

10-20-37-66-2017/10/20

Safety Statements 

46-24/25

RIDADR 

UN 1105 3/PG 3

WGK Germany 

1

RTECS 

SB9800000

HazardClass 

3

PackingGroup 

III

HS Code 

29051990

MSDS

• Language:English Provider:(S)-(-)-sec-Butylcarbinol
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

(S)-(-)-2-Methyl-1-butanol Usage And Synthesis

Chemical Properties

clear colourless liquid

Uses

(S)-(-)-2-Methylbutanol can be used as a reactant to prepare:

• Methylbutyl-2-(3-thienyl)acetate (MBTA) by esterification reaction with 3-thiophene acetic acid in the presence of an acid catalyst.
• (2S)-2-Methyl-1-butanesulfenyl chloride by reacting with thioacetic acid using Mitsunobu reaction conditions.
• (+)-Violapyrone C and (-)-myxalamide A.

Uses

(S)-(?)-2-Methylbutanol can be used to prepare:

• (S)-(?)-2-Methyl-1-butyloxy carbonyl amino hexyl isocyanate (MBI), which is used to synthesize isocyanate copolymers.
• Chiral alkoxynaphathoic acid derivatives having liquid crystalline properties.
• 3,4-Bis[(S)-2-methylbutoxy]thiophene, a key intermediate for the synthesis of polythiophenes.

Definition

ChEBI: The (S)-enantiomer of 2-methylbutan-1-ol.

General Description

rest mainly 3-methyl-1-butanol

Purification Methods

Reflux the butanol with CaO, distil, reflux with magnesium and again fractionally distil it. A small sample of highly purified material is obtained by fractional crystallisation after conversion into a suitable ester such as the trinitrophthalate or the 3-nitrophthalate. The latter is converted to the cinchonine salt in acetone and recrystallised from CHCl3 by adding pentane. The salt is saponified, extracted with ether, and fractionally distilled. [Terry et al. J Chem Eng Data 5 403 1960, Beilstein 1 IV 1666.]

(S)-(-)-2-Methyl-1-butanol(1565-80-6)Related Product Information

• 2-Methyl-1-propanol
• 5-Amino-2-methylpyridine
• 2,6-Lutidine
• 2-Chloro-5-chloromethylpyridine
• 2,5-Dimethylpyridine
• Potassium tert-butoxide
• tert-Butanol
• Kresoxim-methyl
• Ethambutol
• 2,6-Dimethylphenol
• Methyl salicylate
• 1-Methylimidazole
• Tribenuron methyl
• Thiophanate-methyl
• 1-Butanol
• Methyl
• 3-Methyl-1-butanol
• Methyl bromide