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4-Amino-3-fluorophenol

Basic information Safety Supplier Related

4-Amino-3-fluorophenol Basic information

Product Name:
4-Amino-3-fluorophenol
Synonyms:
  • 4-AMINO-3-FLUOROPHENOL
  • 4-Amino-3-fluorphenol
  • 3-FLUORO-4-AMINOPHENOL
  • BUTTPARK 33\04-79
  • IFLAB-BB F2108-0045
  • Aminofluorophenol3
  • 4-Amino-3-Fluorophenol 3-Fluoro-4-Aminophenol
  • 2-FLUORO-4-YDROXYANILINE
CAS:
399-95-1
MF:
C6H6FNO
MW:
127.12
EINECS:
402-230-0
Product Categories:
  • Phenol&Thiophenol&Mercaptan
  • Aromatic Phenols
  • Amines
  • Aromatics
  • Miscellaneous Reagents
Mol File:
399-95-1.mol
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4-Amino-3-fluorophenol Chemical Properties

Melting point:
135-137°C
Boiling point:
270.4±25.0 °C(Predicted)
Density 
1.347±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
soluble in Methanol
pka
9.23±0.18(Predicted)
form 
powder to crystal
color 
Light yellow to Brown
InChI
InChI=1S/C6H6FNO/c7-5-3-4(9)1-2-6(5)8/h1-3,9H,8H2
InChIKey
MNPLTKHJEAFOCA-UHFFFAOYSA-N
SMILES
C1(O)=CC=C(N)C(F)=C1
CAS DataBase Reference
399-95-1(CAS DataBase Reference)
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Safety Information

Hazard Codes 
T,Xi,N
Risk Statements 
22-43-45-51/53
Safety Statements 
45-53-61
RIDADR 
3077
Hazard Note 
Toxic
HazardClass 
9
PackingGroup 
III
HS Code 
29214990

MSDS

  • Language:English Provider:ALFA
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4-Amino-3-fluorophenol Usage And Synthesis

Description

4-amino-3-fluorophenol, a light yellow to brown power, is the raw material of a kind of application medicine, a pesticidal active substance very widely, is a fluorinated insecticide, Phenoxymethyl acetate esters, and benzo pyrrole ketone herbicide, the intermediate of antibacterial and hair dye, etc. Fluoro substituents in the 4-amino-3-fluorophenol molecule increase the lipophile of the whole molecule greatly, thus adding to the membrane permeability of this molecule so that it is suitable as the active component intermediate of some medicines.

Chemical Properties

Dark Brown Solid

Synthesis

Using p-nitrophenol as raw material, after catalytic hydrogenation, a sulfonation reaction is performed first, and then a fluorine substitution reaction is performed to substitute the fluorine at the 3-position. Afterwards, a desulfonation reaction was carried out, and the target product 4-Amino-3-fluorophenol was obtained through extraction.

4-Amino-3-fluorophenol Preparation Products And Raw materials

Raw materials

Preparation Products

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