6-Aminoquinoline Chemical Properties

Melting point:

115-119 °C (lit.)

Boiling point:

146 °C/0.3 mmHg (lit.)

Density 

1.1148 (estimate)

refractive index 

1.7080 (estimate)

Flash point:

146°C/0.3mm

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Chloroform, DMSO, Methanol

form 

Solid

pka

pK1: 5.63(+1) (20°C,μ=0.01)

color 

Pale Brown to Brown

Water Solubility 

Soluble in methanol, chloroform, ethanol, and benzene. Insoluble in water.

Sensitive 

Air Sensitive

BRN 

113320

CAS DataBase Reference

580-15-4(CAS DataBase Reference)

NIST Chemistry Reference

6-Quinolinamine(580-15-4)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/38-36/37/38-20/21/22

Safety Statements 

26-36-36/37/39

RIDADR 

2811

WGK Germany 

3

F 

2-10

HazardClass 

IRRITANT, AIR SENSITIVE

PackingGroup 

III

HS Code 

29334900

MSDS

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6-Aminoquinoline Usage And Synthesis

Chemical Properties

Dark yellow to brown crystalline powder

Uses

6-Aminoquinoline was used as an internal standard in determining serum nicotine and cotinine simultaneously by using high-performance liquid chromatography (HPLC)-fluorometric detection with a postcolumn ultraviolet-photoirradiation system. It was also used as a fluorescent derivatizing agent for the detection of biochemicals and in the synthesis of tertiary N-methylated enaminonesa.

Uses

6-Aminoquinoline is used in the preparation of diaminopyrimidine derivatives as 5-HT4 receptor agonists.

Purification Methods

It is purified by column chromatography on a SiO2 column using CHCl3/MeOH (4:1) as eluent. It crystallises from *C6H6 or *C6H6/pet ether and is an irritant. The styphnate has m 239-240o (from EtOH) and m 242-243o (from aqueous Me2CO). [Barrett et al. J Chem Soc 50, 57 1953, Beilstein 22 III/IV 4681, 22/10 V 303.]

6-Aminoquinoline(580-15-4)Related Product Information

• Bis(2-ethylhexyl)amine
• 6-Hydroxy-2(1H)-3,4-dihydroquinolinone
• Quinhydrone
• Ethoxyquin
• Triallylamine
• 8-Hydroxyquinoline
• QUINOLINE SULPHATE
• Quinclorac
• Isoquinoline
• Dibenzylamine
• 6-NITROQUINOLINE
• 6-AMINO-2-METHYLQUINOLINE
• 5-Nitro-1,10-phenanthroline
• 5-Amino-6-nitroquinoline
• Biotinyl-6-aminoquinoline
• 4-HYDROXY-6-NITROQUINOLINE
• 2-METHYL-6-NITROQUINOLINE
• 5-Aminoquinoline