2-Bromophenol Chemical Properties

Melting point:

5 °C

Boiling point:

195 °C(lit.)

Density 

1.492 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.589(lit.)

Flash point:

108 °F

storage temp. 

Flammables area

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Liquid

pka

8.45(at 25℃)

color 

Clear colorless to slightly yellow

Water Solubility 

soluble

Sensitive 

Light Sensitive

Merck 

14,1428

BRN 

1905115

CAS DataBase Reference

95-56-7(CAS DataBase Reference)

NIST Chemistry Reference

Phenol, 2-bromo-(95-56-7)

EPA Substance Registry System

o-Bromophenol (95-56-7)

Safety Information

Hazard Codes 

Xn,F,Xi

Risk Statements 

10-22-36/37/38

Safety Statements 

16-36/37/39-37/39-26-36

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

RTECS 

SJ7875000

F 

8-10-23

Hazard Note 

Irritant

TSCA 

Yes

HazardClass 

3.2

PackingGroup 

III

HS Code 

29081000

Hazardous Substances Data

95-56-7(Hazardous Substances Data)

MSDS

• Language:English Provider:2-Bromophenol
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Bromophenol Usage And Synthesis

Description

2-Bromophenol is an organic substance in which the C2 position of the benzene ring is replaced by a bromine, also known as o-bromophenol.

Chemical Properties

Clear colorless to slightly yellow liquid.Soluble in chloroform and ether.

Uses

2-Bromophenol is used in organic synthesis to prepare anti-benzofurandiimideand 1-bromodibenzodioxin. It can also be used as a disinfectant.

Definition

ChEBI: 2-bromophenol is a bromophenol. It has a role as a marine metabolite.

Toxicology

2-Bromophenol is moderately acutely orally toxic to mice, and it exhibits strong irritant properties.

Synthesis

To a stirred solution of appropriate organoboronic acids (0.5 mmol, 1.0 equiv.) and Et₃N(1.0 mmol, 2.0 equiv.) in CH₃CN(acetonitrile: 3 mL, H2O: 11μL, 0.6mmol, 1.2 equiv.), DAIB (0.75 mmol, 1.5 equiv.),dissolved in acetonitrile (2mL) was added drop wise at room temperature and the mixture was allowed to stir for 10 minutes at that temperature. After completion of the reaction indicated by TLC, the reaction mixture was washed with distilled water (3×7 mL) and extracted with CH₂Cl₂(3×10 mL). The combined organic phase was dried over Na₂SO₄ and after evaporating the solvent, the residue was purified by column chromatography over silica gel using hexane/EtOAc as eluent to provide the pure target product 2-Bromophenol.

2-Bromophenol(95-56-7)Related Product Information

• 2,4-Dichlorophenol
• 2-Phenylphenol
• 2-Aminophenol
• 4-Aminophenol
• PHENOLDISULFONIC ACID
• 2-Bromobenzonitrile
• 2-Iodophenol
• Guaiacol
• 2-Bromo-4-methylphenol
• Bromochlorophenol Blue sodium salt
• 2,6-Dibromo-4-methylphenol
• Pentabromophenol
• 2,4-DIBROMOANISOLE
• Decabromodiphenyl oxide
• BCP
• 2,6-Dibromophenol
• 2-Bromoanisole
• 2,4-BROMOPHENOL