Isobutyric anhydride Chemical Properties

Melting point:

-56 °C (lit.)

Boiling point:

182 °C (lit.)

Density 

0.954 g/mL at 25 °C (lit.)

vapor density 

5.45 (vs air)

vapor pressure 

10 mm Hg ( 67 °C)

refractive index 

n20/D 1.406(lit.)

Flash point:

152 °F

storage temp. 

Store below +30°C.

form 

Liquid

color 

Clear colorless

explosive limit

1.09%, 87°F

Water Solubility 

decomposes

Sensitive 

Moisture Sensitive

BRN 

386267

Exposure limits

ACGIH: TWA 10 ppm
NIOSH: TWA 10 ppm(30 mg/m3); STEL 15 ppm(45 mg/m3)

Dielectric constant

13.9（20℃）

LogP

1.1 at 25℃

CAS DataBase Reference

97-72-3(CAS DataBase Reference)

NIST Chemistry Reference

Propanoic acid, 2-methyl-, anhydride(97-72-3)

EPA Substance Registry System

Isobutyric anhydride (97-72-3)

Safety Information

Hazard Codes 

C

Risk Statements 

34-21/22

Safety Statements 

26-36/37/39-45

RIDADR 

2922

WGK Germany 

3

RTECS 

NQ5550000

F 

13-21

Autoignition Temperature

624 °F

TSCA 

Yes

HS Code 

2915 90 70

HazardClass 

8

PackingGroup 

II

Hazardous Substances Data

97-72-3(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: 266 mg/kg LD50 dermal Rabbit 475 mg/kg

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Isobutyric anhydride Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

Chemical intermediate.

Uses

Isobutyric anhydride was used in the synthesis of 4-O-isobutyryl derivative via reaction with octyl β-D-glucopyranoside in the presence of C₂-symmetric chiral 4-pyrrolidinopyridine as a catalyst.

Preparation

Isobutyric anhydride is prepared from iso-Butyryl chloride and Sodium acetate, or: from iso-Butyryl chloride and Butyric acid with a catalyst.

Definition

ChEBI: An acyclic carboxylic anhydride of isobutyric acid. Metabolite observed in cancer metabolism.

General Description

A colorless liquid. Flash point 139°F. Burns skin and eyes. Vapors are heavier than air.

Air & Water Reactions

Flammable. Reacts exothermically with water or moisture-containing materials to form isobutyric acid.

Reactivity Profile

Isobutyric anhydride reacts exothermically with water. The reactions are sometimes slow, but can become violent when local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with a cids, strong oxidizing agents, alcohols, amines, and bases.

Hazard

Strong irritant to tissue.

Health Hazard

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Isobutyric anhydride(97-72-3)Related Product Information

• Methyl isobutyrylacetate
• CIS-3-HEXENYL ISOBUTYRATE
• Maltol isobutyrate
• Isobutyryl chloride
• Isobutyric acid
• Ethyl isobutyrate
• Butyl isobutyrate
• Isobutaneboronic acid
• Triethoxyisobutylsilane
• Isobutylmercaptan
• Isobutylene
• 2-Methyl-1-propanol
• ISOBUTYLLITHIUM
• NERYL ISOBUTYRATE
• Methyl isobutyrate
• CINNAMYL ISOBUTYRATE
• ISOBUTYRIC ACID PHENYL ESTER
• Phenoxyethyl isobutyrate