Halofantrine hydrochloride Chemical Properties

Melting point:

93-96°; mp 203-204°

storage temp. 

2-8°C

solubility 

DMSO: >10mg/mL

form 

solid

color 

white to off-white

Major Application

pharmaceutical (small molecule)

InChI

1S/C26H30Cl2F3NO.ClH/c1-3-5-10-32(11-6-4-2)12-9-25(33)23-16-22-21(14-18(27)15-24(22)28)20-13-17(26(29,30)31)7-8-19(20)23;/h7-8,13-16,25,33H,3-6,9-12H2,1-2H3;1H

InChIKey

WANGFTDWOFGECH-UHFFFAOYSA-N

SMILES

Cl.CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c3cc(ccc13)C(F)(F)F

CAS DataBase Reference

36167-63-2(CAS DataBase Reference)

Safety Information

WGK Germany 

3

RTECS 

SF7790000

Storage Class

11 - Combustible Solids

Hazard Classifications

Aquatic Chronic 4

Halofantrine hydrochloride Usage And Synthesis

Chemical Properties

White Solid

Uses

halofantrine, a drug that is effective against chloroquine-resistant malaria and is now being evaluated in Africa.

Uses

Antimalarial.

brand name

Halfan (GlaxoSmithKline).

Biological Activity

Halofantrine is a blocker of delayed rectifier potassium current via the inhibition of hERG channel.

IC 50

Plasmodium

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