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ChemicalBook >  Product Catalog >  Pharmaceutical intermediates >  Heterocyclic compound >  Pyridine compound >  Fluoropyridine >  2,6-Dichloro-3-fluoropyridine

2,6-Dichloro-3-fluoropyridine

Basic information Physical Form Synthesis Safety Supplier Related

2,6-Dichloro-3-fluoropyridine Basic information

Product Name:
2,6-Dichloro-3-fluoropyridine
Synonyms:
  • 2,6-Dichloro-3-fluoropyridine
  • Pyridine, 2,6-dichloro-3-fluoro-
  • 2,6-Dichloro-3-fluoropyridin
  • 2,6-Dichloro-3-fluoropyridine ISO 9001:2015 REACH
CAS:
52208-50-1
MF:
C5H2Cl2FN
MW:
165.98
Product Categories:
  • Fluorine series
Mol File:
52208-50-1.mol
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2,6-Dichloro-3-fluoropyridine Chemical Properties

Melting point:
44-46°C
Boiling point:
196.0±35.0 °C(Predicted)
Density 
1.498±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-3.21±0.10(Predicted)
InChI
InChI=1S/C5H2Cl2FN/c6-4-2-1-3(8)5(7)9-4/h1-2H
InChIKey
YAXSIJLRAOURJK-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(Cl)=CC=C1F
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Safety Information

RIDADR 
2811
HazardClass 
6.1
PackingGroup 
HS Code 
2933399990
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2,6-Dichloro-3-fluoropyridine Usage And Synthesis

Physical Form

White solid

Synthesis

The venerable Balz and Schiemann reaction is the most powerful methodology for preparing aryl fluorides. Not surprisingly, this reaction has been applied to the synthesis of fluoropyridines. Thus, 2,6-dichloro-3-fluoropyridine is readily prepared from 3-amino-2,6-dichloropyridine. The method has been applied to combinatorial synthesis on the solid phase.

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