Tiotropium bromide hydrate
Tiotropium bromide hydrate Basic information
- Product Name:
- Tiotropium bromide hydrate
- Synonyms:
-
- (1R,2R,4S,5S,7S)-7-[2-HYDROXY-2,2-DI(2-THIENYL)ACETOXY]-9,9-DIMETHYL-3-OXA-9-AZONIATRICYCLO[3.3.1.02,4] NONANE BROMIDE MONOHYDRATE
- tiotropium bromide hydrate
- TIOTROPIUM BROMIDE MONOHYDRATE
- TIOTROPIUM BROMDIE
- Tiotropium
- (1a,2b,4b,5a,7b)-7-[(hydroxydi-2-thienylacety l)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide hydrate
- (1a,2b,4b,5a,7b)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide
- TiotropiuM BroMide MonohydrateTiotropiuM BroMide Monohydrate
- CAS:
- 139404-48-1
- MF:
- C19H22BrNO4S2.H2O
- MW:
- 490.43
- EINECS:
- 690-508-4
- Product Categories:
-
- API
- Inhibitors
- 139404-48-1
- Mol File:
- 139404-48-1.mol
Tiotropium bromide hydrate Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Sparingly soluble in water, soluble in methanol, practically insoluble in methylene chloride.
- form
- Powder
- InChIKey
- MQLXPRBEAHBZTK-SEINRUQRSA-M
- CAS DataBase Reference
- 139404-48-1(CAS DataBase Reference)
Tiotropium bromide hydrate Usage And Synthesis
Chemical Properties
White or yellowish-white powder or crystals.
Uses
Tiotropium Bromide hydrate is a hydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor antagonist. Although tiotropium Bromide (Spiriva; Tiova; BA 679BR; tiopropium) doe
Definition
ChEBI: Tiotropium bromide hydrate is a hydrate that is the monohydrate form of tiotropium bromide. Used for maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease. It has a role as a muscarinic antagonist and a bronchodilator agent.
Clinical Use
Maintenance treatment of chronic obstructive pulmonary disease
Drug interactions
Potentially hazardous interactions with other drugs
Avoid administration with other anti-cholinergic
drugs.
Anti-arrhythmics: increased risk of antimuscarinic
side effects with disopyramide.
Metabolism
Tiotropium is excreted largely unchanged in the urine, although it may undergo some metabolism by non-enzymatic cleavage and by the cytochrome P450 isoenzymes CYP2D6 and CYP3A4.
Tiotropium bromide hydrateSupplier
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Tiotropium bromide hydrate(139404-48-1)Related Product Information
- Tiotropium bromide
- 2-Thiophenecarboxaldehyde
- Dimidium bromide
- Chloral hydrate
- ETHANE
- Dacthal
- Dimethyl sulfate
- Allyl bromide
- Rocuronium bromide
- OXITROPIUM BROMIDE
- N,N-Dimethylformamide
- Dimethyl phthalate
- Dimethyl ether
- Dimethyl fumarate
- LACTOSE, MONOHYDRATE
- Thifensulfuron methyl
- Tetrahydrothiophene
- Cephalothin sodium