Sodium picosulfate Chemical Properties

Melting point:

283-286°C

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Freely soluble in water, slightly soluble in ethanol 96 per cent.

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

InChI

InChI=1S/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2

InChIKey

GOZDTZWAMGHLDY-UHFFFAOYSA-L

SMILES

C(C1N=CC=CC=1)(C1=CC=C(OS([O-])(=O)=O)C=C1)C1C=CC(OS([O-])(=O)=O)=CC=1.[Na+].[Na+]

Safety Information

HS Code 

2933399090

Toxicity

mouse,LD50,intraperitoneal,2900mg/kg (2900mg/kg),LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATIONBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977.

MSDS

• Language:English Provider:4,4'-(pyridin-2-ylmethylene)bisphenyl bis (sodiumsulphate)

Sodium picosulfate Usage And Synthesis

Chemical Properties

Off-White Solid

Originator

Guttalax, De Angelini, Italy ,1967

Uses

Sodium picosulfate acts as a stimulant laxative by increasing the frequency and the force of peristalsis and promoting electrolyte and water retention in the colon. Sodium picosulfate is most often used as laxatives.

Uses

Sodium picosulfate is a stimulant laxative related to bis-acedyl; used for the treatment of constipation and for evaluation of the colon by stimulation bowel movements following hydrolysis by colon bacteria.

Definition

ChEBI: Sodium picosulfate is an aryl sulfate and a member of pyridines.

Therapeutic Function

Laxative

Side effects

Major minor side effects for Sodium Picosulfate:Diarrhoea, Abdominal pain, Nausea and vomiting, and Stomach cramps.

Synthesis

The general procedure for the synthesis of (pyridin-2-ylmethylene)bis(4,1-phenylene)bis(sodium sulfate salt) from 4,4'-(pyridin-2-ylmethylene)bisphenol was as follows: the crude product of 4,4'-(pyridin-2-ylmethylene)bisphenol was dissolved in pyridine, and 39.5 g of chlorosulphonic acid was added slowly dropwise over the temperature range from 0 to 10°C. The reaction was carried out with continuous stirring. After the dropwise addition, the temperature was gradually increased to the reaction temperature and the reaction was continuously stirred for 1 hour. Subsequently, the reaction mixture was allowed to stir naturally at room temperature for 4 hours. Upon completion of the reaction, the reaction mixture was slowly poured into ice water and the pH was adjusted to 10 with 6 M sodium hydroxide solution. extraction was carried out with dichloromethane and the aqueous phase was separated and concentrated under reduced pressure. Finally, the product was collected by filtration and dried under vacuum at 40 °C to afford 34.8 g of sodium 4,4'-(pyridin-2-ylmethylene)diphenylsulfite, the product was a white solid with 99.8% purity and 86.4% yield.

References

[1] Patent: CN105175317, 2017, B. Location in patent: Paragraph 0054-0055; 0060

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