meclocycline Chemical Properties

Melting point:

>167°C (dec.)

Boiling point:

837.0±65.0 °C(Predicted)

Density 

1.72±0.1 g/cm3(Predicted)

storage temp. 

Amber Vial, -20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

4.50±1.00(Predicted)

form 

Solid

color 

Yellow to Dark Yellow

Stability:

Light Sensitive

Safety Information

Toxicity

LD50 in mice (mg/kg): >5000 orally, 425 i.p. (Bernardi)

meclocycline Usage And Synthesis

Uses

Meclocycline is a close structural analogue of methacycline which shows antibacterial and antiprotozoan activity.

Uses

Meclocycline is a semi-synthetic tetracycline prepared by dehydration of the 6-hydroxy group of chlortetracycline to yield an exocyclic 6-methylene. Meclocyline is a close structural analogue of methacycline. Like all tetracyclines, meclocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis. Meclocycline has been extensively cited in the literature with over 400 references.

Definition

ChEBI: Meclocycline is a member of tetracyclines.

brand name

Meclan (Johnson & Johnson).

meclocycline(2013-58-3)Related Product Information

• Oxytetracycline
• 1-ACETYL-1-CYCLOHEXENE
• Metacycline hydrochloride
• Sancycline
• 4-(2-Chlorophenyl)-2-methylbut-1-ene
• METHACYCLINE HYDROCHLORIDE
• meclocycline
• 5-Chloro-1-tetralone