cloprednol Chemical Properties

Melting point:

>125°C (dec.)

Boiling point:

600.3±55.0 °C(Predicted)

Density 

1.40±0.1 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

Ethyl Acetate (Slightly), Methanol (Slightly)

pka

12.30±0.70(Predicted)

form 

Solid

color 

White to Off-White

cloprednol Usage And Synthesis

Originator

Syntestan,Syntex,W. Germany,1980

Uses

A systematic corticosteroid. Anti-inflammatory.

Definition

ChEBI: Cloprednol is a 21-hydroxy steroid.

Manufacturing Process

A mixture of 5 g of the 21-acetate of 6α-chlorohydrocortisone, 7 g of chloranil and 100 cc of n-amyl alcohol was refluxed for 16 hours, cooled and diluted with ether. The solution was successively washed with water, 5% sodium carbonate solution and water, dried over anhydrous sodium sulfate, filtered and evaporated to dryness under reduced pressure. Chromatographic purification of the residue yielded the 21-acetate of 6-chloro-δ1,4,6- pregnatriene-11β,17α,21-triol-3,20-dione.

Therapeutic Function

Glucocorticoid

cloprednol(5251-34-3)Related Product Information

• Dexamethasone
• Dexamethasone 21-phosphate disodium salt
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• Tamoxifen
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• Clomifene
• CHLOROPROPANOL, MIXED ISOMERS
• 3-Chloro-2-methylpropene
• cloprednol
• 2-Chlorododec-1-ene
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• delmadinone
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• CIS-9, TRANS-11-TETRADECADIENOL
• DODECENYL CHLORIDE