butropium bromide Chemical Properties

Melting point:

166-168oC

alpha 

D20 -21.7° (c = 0.5 in water)

storage temp. 

Refrigerator

solubility 

DMSO (Slightly), Methanol (Slightly, Sonicated)

form 

Solid

color 

White to Off-White

Safety Information

Toxicity

LD50 in male mice (mg/kg): 1500 orally; 660 s.c.; 12.0 i.v. (Tanaka, Hashimoto, 1972)

butropium bromide Usage And Synthesis

Chemical Properties

Crystalline Solid

Originator

Coliopan,Eisai,Japan,1974

Uses

Anticholinergic. Antispasmodic.

Definition

ChEBI: Butropium bromide is an organic bromide salt of butropium. It is a drug which suppresses spasm of smooth muscles of internal organs, inhibits gastric acid secretion and relieves abdominal pain. It is used in the treatment of spasmodic pains associated with gastritis, gastric ulcers and cholelithiasis. It has a role as an antispasmodic drug and a muscarinic antagonist. It is an organic bromide salt and a quaternary ammonium salt. It contains a butropium.

Manufacturing Process

To 100 ml of an isopropanol solution containing 11.8 grams of hyoscyamine base were added drop by drop with stirring 10 ml of an isopropanol solution containing 11 grams of p-n-butoxybenzyl bromide. After a while, the reaction mixture had a turbid appearance followed by separation of white crystals.
After stirring for 5 hours at room temperature, the crystals were recovered by filtration, which were then recrystallized from 120 ml of isopropanol. There was obtained 15.8 grams of white needles having the melting point of 158°- 160°C.

Therapeutic Function

Spasmolytic

butropium bromide(29025-14-7)Related Product Information

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