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1-butylbiguanide

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1-butylbiguanide Basic information

Product Name:
1-butylbiguanide
Synonyms:
  • N-BUTYLBIGUANIDINE
  • Buformin
  • Buformin (base and/or unspecified salts)
  • Buformine
  • Butformin
  • Butylbiguanide
  • Butyldiguanide
  • DBV
CAS:
692-13-7
MF:
C6H15N5
MW:
157.2168
EINECS:
2117264
Product Categories:
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
692-13-7.mol
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1-butylbiguanide Chemical Properties

Melting point:
174-176 °C
Boiling point:
271.89°C (rough estimate)
Density 
1.0291 (rough estimate)
refractive index 
1.8070 (estimate)
pka
12.27±0.10(Predicted)
InChI
InChI=1S/C6H15N5/c1-2-3-4-10-6(9)11-5(7)8/h2-4H2,1H3,(H6,7,8,9,10,11)
InChIKey
XSEUMFJMFFMCIU-UHFFFAOYSA-N
SMILES
C(=N)(NCCCC)NC(=N)N
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1-butylbiguanide Usage And Synthesis

Uses

Buformin, clinically used for diabetes mellitus, is known to improve resistance to insulin in patients. It suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase

Definition

ChEBI: Buformin is a member of the class of biguanides that is biguanide substituted by a butyl group at position 1. It is an antidiabetic drug with potential antitumor effect. It has a role as a hypoglycemic agent, a geroprotector, a radiosensitizing agent, an antineoplastic agent and an antiviral agent. It is functionally related to a biguanide.

brand name

Adebit;Andebit;Andelit;Andere;Biforon;Bigunal;Biquinal;Bs-5892;Bufonamin;Bulbonin;Diabrin;Dutformin;Gliporal;Insulamin;Krebon;Panformin;Silubin retard;Sindiatil;Tidemol retard;Ziavetine.

World Health Organization (WHO)

Buformin is an analogue of phenformin. See WHO comment for phenformin. (Reference: (WHODI) WHO Drug Information, 2, 4, 1977)

in vivo

Buformin (oral administation; 7.6?mmol/kg of chow; 7 days) exhibits significantly reduced tumor volumes and weights, and?hinders mammary morphogenesis and proliferation in MMTV-erbB-2 transgenic mice[1]

Animal Model:Female MMTV-erbB-2 transgenic mice[1]
Dosage:7.6?mmol/kg
Administration:Oral administation; 7 days
Result:Inhibited mammary syngeneic tumor growth in MMTV-erbB-2 transgenic mice.

1-butylbiguanideSupplier

Chengdu Kaitaichuang Pharmaceutical Technology Co., Ltd Gold
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16608035117
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1350095594@qq.com
LGM Pharma
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1-(800)-881-8210
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inquiries@lgmpharma.com
BOC Sciences
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1-631-485-4226; 16314854226
Email
info@bocsci.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185
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sales-cpd@caerulumpharma.com
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Email
sales@xiyashiji.com
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