4-amino-3,5-dichloro-6-fluoro-2-pyridone Chemical Properties

Boiling point:

134.7±40.0 °C(Predicted)

Density 

1.69±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

3.54±0.20(Predicted)

Appearance

White to off-white Solid

4-amino-3,5-dichloro-6-fluoro-2-pyridone Usage And Synthesis

Synthesis

The general procedure for the synthesis of 6-fluoro-3,5-dichloro-4-amino-2-hydroxypyridine using 2,6-difluoro-3,5-dichloro-4-aminopyridine as starting material was as follows: accurately weighed 80 mmol of 2,6-difluoro-3,5-dichloro-4-amino-pyridine in a reaction flask, and 5,000 mL of N,N-dimethylacetamide (DMAC) was added to dissolve it completely. A 40 wt% aqueous sodium hydroxide solution was slowly added dropwise with continuous stirring. After the dropwise addition was completed, the reaction system was warmed up to 100 °C and the reaction was maintained at this temperature for 3 hours. After completion of the reaction, the mixture was cooled to room temperature and the target compound 6-fluoro-3,5-dichloro-4-amino-2-hydroxypyridine (Compound I) was isolated by suitable method in 94.5% yield.

References

[1] Patent: CN107311924, 2017, A. Location in patent: Paragraph 0060-0064; 0065-0069; 0070-0074

4-amino-3,5-dichloro-6-fluoro-2-pyridone(94133-62-7)Related Product Information

• 4-amino-3,5-dichloro-6-fluoro-2-pyridone
• 3,5-DICHLORO-2-PYRIDONE