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N-Demethyl olanzapine

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N-Demethyl olanzapine Basic information

Product Name:
N-Demethyl olanzapine
Synonyms:
  • 2-Methyl-4-(1-Piperazinyl)-10H-Thieno-[2,3-b][1,5]Benzodiazepine
  • 4'-Desmethylolanzapine
  • Desmethylolanzapine
  • LY 170055
  • Olanzapine impurity 14/N-Demethyl Olanzapine
  • Olanzapine-6
  • Olanzapine impurity 10/N-Demethyl Olanzapine/2-methyl-4-(1-piperazinyl)-10H-Thieno[2,3-b][1,5]benzodiazepine
  • Olanzapine EP Impurity G
CAS:
161696-76-0
MF:
C16H18N4S
MW:
298.41
Product Categories:
  • Metabolites
  • Olanzapine
Mol File:
161696-76-0.mol
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N-Demethyl olanzapine Chemical Properties

Melting point:
144.5°C
Boiling point:
489.2±55.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
Flash point:
13℃
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml,Ethanol: 10 mg/ml
form 
A solid
pka
8.58±0.10(Predicted)
color 
White to off-white
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Safety Information

Hazard Codes 
F,Xn
Risk Statements 
11-20/21/22-36
Safety Statements 
16-26-36/37
RIDADR 
UN 1648 3 / PGII
WGK Germany 
2
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N-Demethyl olanzapine Usage And Synthesis

Chemical Properties

Brown Solid

Uses

A metabolite of Olanzapine.

Definition

ChEBI: 4'-N-desmethylolanzapine is a benzodiazepine.

General Description

Desmethylolanzapine is the primary metabolite of olanzapine, marketed as the atypical antipsychotic Zyprexa?for the treatment of schizophrenia and bipolar disorder. This new certified solution standard is suitable for use in LC or GC applications including clinical toxicology analysis, forensic testing, or therapeutic drug monitoring.

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