Bifemelane HCl Chemical Properties

Melting point:

117-121°

solubility 

Soluble to 100 mM in water and to 100 mM in DMSO

form 

Powder

Safety Information

Toxicity

LD50 in mice, rats (mg/kg): 1000, 1080 orally; 173, 130 i.p. (Tobe, 1981)

Bifemelane HCl Usage And Synthesis

Description

Bifemelane is a nootropic reported to have antianoxic, anti-ischemic and memory enhancing activities. In man, bifemelane appears to increase cerebral blood flow, while in rodents it reverses scopolamine-induced dementia. Bifemelane has an added adrenergic component reportedly arising from norepinephrine uptake inhibition.

Originator

Mitsubishi; Eisai (Japan)

Uses

Bifemelane Hydrochloride, is an antidepressant MAO inhibitor. It has also been reported to protect neural tissues against ischemic damage and age-related neurodegeneration.

Manufacturing Process

N-Methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine was prepared from 2- (5-bromopentyloxy)diphenylmethane and of methylamine in ethanol is at 50°C in a sealed tube (heating for 3 hours). Ethanol and excess methylamine are distilled in vacuo, 2 N NaOH aqueous solution is added, and the reaction product is extracted with ether. Dry hydrogen chloride gas is passed into the ether solution, and the precipitate collected by filtration. Recrystallization from ethanol-ether gives N-methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine hydrochloride, m.p. 87.5-89.5°C.

brand name

Alnert; Celeport

Therapeutic Function

Antidepressant, Antiulcer, Nootropic

Hazard

Moderately toxic by ingestion.

storage

Desiccate at RT

Bifemelane HCl(62232-46-6)Related Product Information

• 2-BENZYL-4-CHLOROPHENYL 4-PIPERIDINYLMETHYL ETHER
• Bifemelane HCl
• 4-[(2-BENZYLPHENOXY)METHYL]PIPERIDINEHYDROCHLORIDE
• BIFEMELANE