2-chloro-5-aminomethylthiazole Chemical Properties

Melting point:

121 °C

Boiling point:

274.7±32.0 °C(Predicted)

Density 

1.427±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

7.68±0.29(Predicted)

form 

Oil

color 

Colourless to Yellow

Stability:

Hygroscopic

2-chloro-5-aminomethylthiazole Usage And Synthesis

Uses

(2-Chlorothiazol-5-yl)methanamine is a metabolite of Thiamethoxam (T344180), a neonicotinoid insecticide.

Synthesis

General procedure for the synthesis of (2-chlorothiazol-5-yl)methanamine using 2-((2-chlorothiazol-5-yl)methyl)isodihydroindole-1,3-dione as starting material: 25.3 g of the above off-white solid and 150 mL of ethanol were added to a 250 mL three-necked flask in a unit equipped with a magnetic stirrer, a condenser tube and a drying tube. 9.1 g of hydrazine hydrate was slowly added dropwise to the reaction system. Subsequently, the reaction mixture was heated to reflux for 4-6 hours. Upon completion of the reaction, the solvent was evaporated under reduced pressure to afford 9.1 g of (2-chlorothiazol-5-yl)methylamine, the product was in the form of an orange oil.

References

[1] Patent: US2015/51402, 2015, A1. Location in patent: Page/Page column 0075

2-chloro-5-aminomethylthiazole(120740-08-1)Related Product Information

• 2-Chlorothiazole
• 4-[(2-CHLORO-1,3-THIAZOL-5-YL)METHYL]MORPHOLINE
• 1-[(2-CHLORO-1,3-THIAZOL-5-YL)METHYL]-4-METHYLPIPERAZINE
• 1-[(2-CHLORO-1,3-THIAZOL-5-YL)METHYL]PIPERIDINE
• 2-CHLORO-5-(1H-PYRAZOL-1-YLMETHYL)-1,3-THIAZOLE
• 1-[(2-CHLORO-1,3-THIAZOL-5-YL)METHYL]-1H-INDOLE
• 2-[(2-CHLORO-1,3-THIAZOL-5-YL)METHYL]-1,2,3,4-TETRAHYDROISOQUINOLINE
• 1-[(2-CHLORO-1,3-THIAZOL-5-YL)METHYL]-1,2,3,4-TETRAHYDROQUINOLINE
• 1-[(2-CHLORO-1,3-THIAZOL-5-YL)METHYL]-4-(2-FLUOROPHENYL)PIPERAZINE
• N-[(2-CHLORO-1,3-THIAZOL-5-YL)METHYL]-3-METHOXY-1-PROPANAMINE
• 1-[(2-CHLORO-1,3-THIAZOL-5-YL)METHYL]-4-[3-(TRIFLUOROMETHYL)PHENYL]PIPERAZINE
• N-BENZYL(2-CHLORO-1,3-THIAZOL-5-YL)-N-METHYLMETHANAMINE
• 1-BENZYL-4-[(2-CHLORO-1,3-THIAZOL-5-YL)METHYL]PIPERAZINE
• 2-[(4-CHLOROBENZYLIDENE)AMINO]-3-([(2,4-DICHLORO-1,3-THIAZOL-5-YL)METHYL]AMINO)BUT-2-ENEDINITRILE
• 2-(BENZYLIDENEAMINO)-3-([(2,4-DICHLORO-1,3-THIAZOL-5-YL)METHYL]AMINO)BUT-2-ENEDINITRILE
• 1-[(2-CHLORO-1,3-THIAZOL-5-YL)METHYL]-4-PHENYLPIPERAZINE
• 2-[(2,6-DICHLOROBENZYLIDENE)AMINO]-3-([(2,4-DICHLORO-1,3-THIAZOL-5-YL)METHYL]AMINO)BUT-2-ENEDINITRILE
• 2-CHLORO-5-(1H-IMIDAZOL-1-YLMETHYL)-1,3-THIAZOLE