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3-Aminopyridine-2-carboxylic acid methyl ester

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3-Aminopyridine-2-carboxylic acid methyl ester Basic information

Product Name:
3-Aminopyridine-2-carboxylic acid methyl ester
Synonyms:
  • 3-Aminopyridine-2-carboxylic acid methyl ester
  • 2-Pyridinecarboxylicacid,3-amino-,methylester(9CI)
  • methyl 3-aminopyridine-2-carboxylate
  • Methyl 3-aminopicolinate
  • 2-Pyridinecarboxylic acid, 3-aMino-, Methyl ester
  • 3-AMINOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER(RS20012789)
  • Methyl 3-amino-2-pyridine carboxylate
  • 3-Aminopyridine-2-carboxylic acid methyl ester ISO 9001:2015 REACH
CAS:
36052-27-4
MF:
C7H8N2O2
MW:
152.15
Product Categories:
  • Heterocycle-Pyridine series
  • Esters
  • GLYCINESCAFFOLD
  • Pyridines
Mol File:
36052-27-4.mol
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3-Aminopyridine-2-carboxylic acid methyl ester Chemical Properties

Boiling point:
317.3±22.0 °C(Predicted)
Density 
1.238±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
2.65±0.10(Predicted)
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3-Aminopyridine-2-carboxylic acid methyl ester Usage And Synthesis

Uses

3-Aminopyridine-2-carboxylic acid methyl ester can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Synthesis


To a solution of 3-aminopyridine-2-carboxylic acid (20 g, 144.9 mmol) in methanol (300 mL) was added conc. sulfuric acid (5.4 mL), and the mixture was heated under reflux for 5 days. The reaction mixture was concentrated under reduced pressure, water was added thereto, and sodium carbonate was added thereto until the complete of foaming. The mixture was extracted with dichloromethane (x3), the organic layer was dried over sodium sulfate, and the solvent was evaporated under reduced pressure to give methyl 3-aminopyridine-2-carboxylate (17.0 g, 77%) as a pale yellow solid. 1H-NMR(300MHz,CDCl3):δ3.95(3H,s),5.72(2H,brs),7.03(1H,dd,J=0.99,8. 35Hz),7.18-7.21(1H,m),8.05(1H,dd,J=0.96,4.04Hz).

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