CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P Chemical Properties

Melting point:

71-73°C

Boiling point:

422.8±44.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: ≥10mg/mL

pka

-1.08±0.20(Predicted)

form 

solid

color 

white to off-white

Safety Information

WGK Germany 

3

CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P Usage And Synthesis

Uses

It is one of a series of AMPA modulators matergic AMPA receptors.

Uses

CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.

General Description

CX546, a benzoylpiperidine derivative ampakine is an analog of CX516.

Biological Activity

AMPA receptor potentiator. Binds specifically to the agonist bound non-desensitized receptor, most likely destabilizing the desensitized receptor conformation. Enhances cognitive function in rats.

Biochem/physiol Actions

CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI)?in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.

storage

Store at +4°C

CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P(215923-54-9)Related Product Information

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