ChemicalBook > Product Catalog > Organic Chemistry > Heterocyclic Compounds > (2S,5R)-7-oxo-2-((((R)-pyrrolidin-3-yl)oxy)carbamoyl)-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate
(2S,5R)-7-oxo-2-((((R)-pyrrolidin-3-yl)oxy)carbamoyl)-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate
(2S,5R)-7-oxo-2-((((R)-pyrrolidin-3-yl)oxy)carbamoyl)-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate Basic information
- Product Name:
- (2S,5R)-7-oxo-2-((((R)-pyrrolidin-3-yl)oxy)carbamoyl)-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate
- Synonyms:
-
- (2S,5R)-7-oxo-2-((((R)-pyrrolidin-3-yl)oxy)carbamoyl)-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate
- Sulfuric acid, mono[(1R,2S,5R)-7-oxo-2-[[[(3R)-3-pyrrolidinyloxy]amino]carbonyl]-1,6-diazabicyclo[3.2.1]oct-6-yl] ester
- CAS:
- 1452458-70-6
- MF:
- C11H18N4O7S
- MW:
- 350.35
- Mol File:
- 1452458-70-6.mol
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(2S,5R)-7-oxo-2-((((R)-pyrrolidin-3-yl)oxy)carbamoyl)-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate Chemical Properties
- Density
- 1.68±0.1 g/cm3(Predicted)
- pka
- -4.59±0.18(Predicted)
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(2S,5R)-7-oxo-2-((((R)-pyrrolidin-3-yl)oxy)carbamoyl)-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate Usage And Synthesis
Uses
FPI-1465 acts a dual inhibitor of serine-β-Lactamases and Penicillin-binding proteins (PBPs).FPI-1465 inhibits PBP2 (IC50=1.0 μg/mL). FPI-1465 exhibits activity against β-lactamase CTX-M-15 and OXA-48 with Kds of 0.011 and 5.3 μM, respectively[1].
References
[1] Andrew M King,?et al. Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins. ACS Chem Biol.?2016 Apr 15;11(4):864-8. DOI:10.1021/acschembio.5b00944