magnessium lithospermate B
magnessium lithospermate B Basic information
- Product Name:
- magnessium lithospermate B
- Synonyms:
-
- MAGNESIUM LITHOSPERMATE B 98%
- Monomethyl lithospermate B
- magnessium lithospermate B
- magnesium,2-[(E)-3-[3-[1-carboxylato-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyl]oxy-3-(3,4-dihydroxyphenyl)propanoate
- Magnesium Salvianolate B
- Magnesium Lithospermate B
- Magnesium Lithospermate B, 10 mM in DMSO
- CAS:
- 122021-74-3
- MF:
- C36H28MgO16
- MW:
- 740.90292
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 122021-74-3.mol
magnessium lithospermate B Chemical Properties
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- color
- Light yellow to light brown
magnessium lithospermate B Usage And Synthesis
Uses
Magnesium Lithospermate B, is a derivative of caffeic acid tetramer and an inhibitor of Na+/K+ ATPase, which can be extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroin?ammation and attenuates neurodegeneration[1][2][3].
in vivo
Magnesium Lithospermate B (2-8 mg/kg; p.o. once daily for 16 d) reduces the renal damage of oxidative stress through reduction of reactive oxygen species in old rats[1].
Magnesium Lithospermate B (0.5 μg/g; s.c. for 6 weeks) promotes the neurogenesis and improves the memory in PD models[3].
| Animal Model: | Young (5-month-old) and old (20-month-old) specific-pathogen-free male Sprague-Dawley rats[1] |
| Dosage: | 2, 8 mg/kg |
| Administration: | P.o. once daily for 16 days |
| Result: | Reduced the protein expression of major subunits of nicotinamide adenine dinucleotide phosphate oxidase (Nox4 and p22phox), phospho-p38, nuclear factor-kappa B p65, cyclooxygenase-2, and inducible nitric oxide synthase. Showed lower levels of senescence-related proteins such as p16, ADP-ribosylation factor 6, p53, and p21. |
target
p65 | NF-kB | TGF-β/Smad | ROS | PDGFR
References
[1] Magnesium lithospermate B possesses inhibitory activity on Na+,K+‐ATPase and neuroprotective effects against ischemic stroke
[2] Park CH, et, al. Magnesium Lithospermate B from Salvia miltiorrhiza Bunge Ameliorates Aging-Induced Renal Inflammation and Senescence via NADPH Oxidase-Mediated Reactive Oxygen Generation. Phytother Res. 2017 May;31(5):721-728. DOI:10.1002/ptr.5789
[3] Quan W, et, al. Antioxidant properties of magnesium lithospermate B contribute to the cardioprotection against myocardial ischemia/reperfusion injury in vivo and in vitro. J Tradit Chin Med. 2013 Feb; 33(1): 85-91. DOI:10.1016/s0254-6272(13)60106-5
[4] Zhang Z, et, al. Magnesium lithospermate B promotes proliferation and differentiation of neural stem cells in vitro and enhances neurogenesis in vivo. Tissue Cell. 2018 Aug; 53:8-14. DOI:10.1016/j.tice.2018.05.012
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magnessium lithospermate B(122021-74-3)Related Product Information
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- CAPE
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