ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE Chemical Properties

Melting point:

280-283℃

Boiling point:

373.2±37.0 °C(Predicted)

Density 

1.277

storage temp. 

Sealed in dry,Room Temperature

pka

2.72±0.50(Predicted)

Appearance

Light brown to brown Solid

InChI

InChI=1S/C13H13NO4/c1-3-18-13(16)10-7-14-11-5-4-8(17-2)6-9(11)12(10)15/h4-7H,3H2,1-2H3,(H,14,15)

InChIKey

VNGGYIBIGOOVNP-UHFFFAOYSA-N

SMILES

N1C2C(=CC(OC)=CC=2)C(O)=C(C(OCC)=O)C=1

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26

WGK Germany 

3

HS Code 

2933499090

ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE Usage And Synthesis

Synthesis

A solution was prepared from diethyl 2-[(4-methoxyanilino)methylene]malonate (CAS: 83507-70-4, 71.4 g, 0.24 mol) in 150 mL of diphenyl ether. The reaction system was placed in a metal bath and slowly heated to 243 °C and maintained at this temperature for 3 hours. During the reaction, 15 mL of liquid was distilled. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently dissolved by adding 250 mL of hexane. After stirring the mixture for 3 hours, a filtration operation was performed. The resulting solid was washed with hexane and dried to give ethyl 4-hydroxy-6-methoxyquinoline-3-carboxylate (25.0 g, 0.10 mol, 41% yield), the purity of which meets the requirements for direct use in subsequent reactions. The structure of the product was confirmed by 1H-NMR (CDCl3) and LC-MS: 1H-NMR (CDCl3) δ= 1.28 (t, 3H), 3.85 (s, 3H), 4.21 (q, 2H), 7.34 (dd, 1H), 7.55-7.62 (m, 2H), 8.49 (s, 1H); LC-MS: Rt = 1.17 min ; MS: m/z = 248 [M + 1]+.

References

[1] Patent: WO2006/2047, 2006, A2. Location in patent: Page/Page column 60
[2] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 1 - 16
[3] Organic Process Research and Development, 2014, vol. 18, # 11, p. 1482 - 1491
[4] Tetrahedron Letters, 2017, vol. 58, # 8, p. 794 - 796
[5] Journal of the American Chemical Society, 1946, vol. 68, p. 1204,1206

ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE(77156-78-6)Related Product Information

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