(+)-PINORESINOL Chemical Properties

Melting point:

112 °C

Boiling point:

556.5±50.0 °C(Predicted)

Density 

1.385 g/cm3

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO: ≥6mg/mL

pka

9.54±0.35(Predicted)

form 

Solid

color 

white to tan

LogP

1.591 (est)

Safety Information

WGK Germany 

3

(+)-PINORESINOL Usage And Synthesis

Description

(+)-Pinoresinol is a lignan that has been found in Forsythia and virgin olive oils and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties. It is an inhibitor of α-glucosidase and maltase (IC₅₀s = 492 and 34.3 μM in Baker’s yeast and rat small intestine, respectively). (+)-Pinoresinol scavenges ABTS , but not 2,2-diphenyl-1-picrylhydrazyl (DPPH; ), radicals in cell-free assays (IC₅₀s = 13.43 and >200 μg/ml, respectively). It is cytotoxic to A549, HepG2, and MCF-7, but not U251 and Bcap-37, cells with IC₅₀ values of 29.35, 62.35, 75.32, >80, and >80 μM, respectively. (+)-Pinoresinol prevents cell death induced by glutamate in HT22 cells (EC₅₀ = 6.96 μM) and inhibits LPS-induced nitric oxide production in RAW 264.7 cells (IC₅₀ = 7.89 μM).

Uses

(+)-Pinoresinol is a lignan found in olive oil and in other plants. This phenolic compound was reported to have antioxidant and anticancer potential.

Definition

ChEBI: An enantiomer of pinoresinol having (+)-1S,3aR,4S,6aR-configuration.

(+)-PINORESINOL(487-36-5)Related Product Information

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