Basic information Safety Supplier Related

INDOMETHACIN SODIUM SALT TRIHYDRATE

Basic information Safety Supplier Related

INDOMETHACIN SODIUM SALT TRIHYDRATE Basic information

Product Name:
INDOMETHACIN SODIUM SALT TRIHYDRATE
Synonyms:
  • INDOMETHACIN SODIUM SALT TRIHYDRATE
  • 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, sodi um salt, trihydrate
  • INDOMETACIN FARNESIL
  • 1H-Indole-3-aceticacid, 1-(4-chlorobenzoyl)-5-Methoxy-2-Methyl-, sodiuM salt, hydrate (1:1:3)
  • Indometacin Sodium
  • Sodium salt trihydrate
  • sodium,2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate,trihydrate
  • Indomethacin sodium hydrate
CAS:
74252-25-8
MF:
C34H40ClNO4
MW:
562.146
Mol File:
74252-25-8.mol
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INDOMETHACIN SODIUM SALT TRIHYDRATE Chemical Properties

storage temp. 
4°C, protect from light, stored under nitrogen
solubility 
DMSO: 5 mg/mL (11.53 mM)
form 
Solid
color 
Light yellow to yellow
Water Solubility 
Water: 33.33 mg/mL (76.83 mM)
InChIKey
CFIGYZZVJNJVDQ-LMJOQDENSA-N
SMILES
C12C=CC(OC)=CC=1C(=C(C)N2C(=O)C1C=CC(Cl)=CC=1)CC(=O)OC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/C
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INDOMETHACIN SODIUM SALT TRIHYDRATE Usage And Synthesis

Uses

Anti-inflammatory.

brand name

Indocin (Ovation).

Hazard

A poison by ingestion.

in vivo

Indomethacin sodium hydrate can be used to create gastric ulcer models. After oral administration, the drug is absorbed rapidly and completely, although there are interindividual and intraindividual variations. The plasma peak concentration of 2-3 μg/mL is typically reached within 1-2 hours. However, coadministration with food reduces and delays the peak concentration without affecting the total absorption. At therapeutic concentrations, 90% of Indomethacin is bound to albumin in the plasma[4].

Induction of gastric ulceration[5][6]
Background
Indomethacin can cause gastric ulceration by various mechanisms, including injury through inhibition of prostaglandin (PG) synthesis, reduction in local blood flow, regional irritation, and inhibition of tissue regeneration.
Specific Modeling Methods
Rat: albino Sprague-Dawley ? male ? adult (period: 2 weeks)
Administration: 100 mg/kg ? p.o. ? single dose
Note
(1) All animals fasted 24 h before drug administration.
(2) Indomethacin were dissolved in saline with 5% NaOH.
Modeling Indicators
Gastric tissue macroscopic alterations: Showed prominent mucosal folds and severe erosion, pronounced ulceration and bleeding foci in the gastric mucosa.
Histopathological changes: Showed severe erosion of the mucosa, reaching down to the lamina muscularis; observed hemorrhagic infiltration, edema in the submucosa, and severe hyperemia of the vessels.
Molecular changes: Showed intense Tnf-α expression.
Biochemical changes: Increased MDA, TOS levels, reduced TAS levels, CAT and GPx activities and GSH levels.
Correlated Product(s): Indomethacin sodium hydrate (HY-14397A)
Opposite Product(s): Carnosic acid (HY-N0644)

Animal Model:Male Sprague-Dawley rats[1]
Dosage:0.01-10 mg/kg
Administration:Oral administration; for 3 hours
Result:Inhibited the carrageenan-induced rat paw oedema (ED50=2.0?mg/kg) and hyperalgesia (ED50=1.5?mg/kg) in a dose-dependent manner.
Animal Model:Male C57BL/6J mice[2]
Dosage:10 mg/mL
Administration:Oral administration; daily, for 29 days
Result:Delayed the onset of tumor growth and the initial growth rate of the footpad tumors.

INDOMETHACIN SODIUM SALT TRIHYDRATESupplier

Jiangxi ravel Biotechnology Co.,Ltd Gold
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400-880-2824 18107960669
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Jinan Jinchi Pharmaceutical Technology Co., LTD Gold
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15168890063 18888326116
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Hubei Yuanmeng Biotechnology Co., Ltd Gold
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027-68897569 18120462897
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XiaoGan ShenYuan ChemPharm co,ltd
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15527768836
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Chizhou Kailong Import and Export Trade Co., Ltd.
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Email
xg01_gj@163.com
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INDOMETHACIN SODIUM SALT TRIHYDRATE(74252-25-8)Related Product Information