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Irsogladine maleate

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Irsogladine maleate Basic information

Product Name:
Irsogladine maleate
Synonyms:
  • 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazinemaleate
  • 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazinmaleate
  • 3,5-triazine-2,4-diamine,6-(2,5-dichlorophenyl)-(z)-2-butenedioate(1:1)
  • gaslon
  • mn-1695
  • 2,4-diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine maleate
  • Irsogladin maleate
  • Gaslon N
CAS:
84504-69-8
MF:
C13H11Cl2N5O4
MW:
372.16
Product Categories:
  • Amines
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
84504-69-8.mol
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Irsogladine maleate Chemical Properties

Melting point:
181-182°C
storage temp. 
Inert atmosphere,Room Temperature
Water Solubility 
Insoluble in water
solubility 
DMF:30.0(Max Conc. mg/mL);80.61(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);80.61(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.67(Max Conc. mM)
form 
White crystalline powder.
color 
White to Almost white
Merck 
14,5102
CAS DataBase Reference
84504-69-8(CAS DataBase Reference)
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Safety Information

RTECS 
XY5930000
HS Code 
2933.69.6050
Toxicity
LD50 in male, female mice, rats (mg/kg): 6035, 5697, 3898, 2917 orally; 2841, 3216, 1600, 1524 s.c.; 775, 1006, 558, 545 i.p. (Ueda, 1984 p 474)
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Irsogladine maleate Usage And Synthesis

Description

Irsogladine is a gastroprotective agent. It increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC). Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME . It also inhibits superoxide anion production induced by fMLP and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram .

Chemical Properties

White Solid

Uses

An anti-ulcer drug. Potent PDE4 inhibitor

Uses

antiulcerative;selective PDE4 inhibitor which also enhances gap junction intercellular communication

Definition

ChEBI: Irsogladine maleate is a dichlorobenzene.

Biological Activity

Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.

Irsogladine maleate Preparation Products And Raw materials

Preparation Products

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