Irsogladine maleate
Irsogladine maleate Basic information
- Product Name:
- Irsogladine maleate
- Synonyms:
-
- 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazinemaleate
- 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazinmaleate
- 3,5-triazine-2,4-diamine,6-(2,5-dichlorophenyl)-(z)-2-butenedioate(1:1)
- gaslon
- mn-1695
- 2,4-diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine maleate
- Irsogladin maleate
- Gaslon N
- CAS:
- 84504-69-8
- MF:
- C13H11Cl2N5O4
- MW:
- 372.16
- Product Categories:
-
- Amines
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 84504-69-8.mol
Irsogladine maleate Chemical Properties
- Melting point:
- 181-182°C
- storage temp.
- Inert atmosphere,Room Temperature
- Water Solubility
- Insoluble in water
- solubility
- DMF:30.0(Max Conc. mg/mL);80.61(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);80.61(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.67(Max Conc. mM) - form
- White crystalline powder.
- color
- White to Almost white
- Merck
- 14,5102
- CAS DataBase Reference
- 84504-69-8(CAS DataBase Reference)
Irsogladine maleate Usage And Synthesis
Description
Irsogladine is a gastroprotective agent. It increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC). Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME . It also inhibits superoxide anion production induced by fMLP and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram .
Chemical Properties
White Solid
Uses
An anti-ulcer drug. Potent PDE4 inhibitor
Uses
antiulcerative;selective PDE4 inhibitor which also enhances gap junction intercellular communication
Definition
ChEBI: Irsogladine maleate is a dichlorobenzene.
Biological Activity
Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.
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Irsogladine maleate(84504-69-8)Related Product Information
- Disodium fumarate
- 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine maleate
- Cinepazide maleate
- 1,3,5-Triazine
- Chlorphenamine maleate
- Maleic acid
- 3,4'-DIAMINODIPHENYLMETHANE
- Irsogladine
- Dichloromethylphenylsilane
- Dichlorodiphenylsilane
- Fumaric acid
- Enalapril maleate
- CIS-BUTENEDIOIC ANHYDRIDE
- Chlorobenzene
- Irsogladine maleate