Tamsulosin hydrochloride Chemical Properties

Melting point:

254-256 °C

solubility 

DMSO (Slightly), Methanol (Slightly), Water (Slightly)

Safety Information

HS Code 

2935909550

Tamsulosin hydrochloride Usage And Synthesis

Chemical Properties

White to Off-White Solid

Uses

Tamsulosin is a specific α1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy.

Uses

Tamsulosin hydrochloride is a specific ;1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy.

Clinical Use

Treatment of benign prostatic hyperplasia

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Antidepressants: enhanced hypotensive effect with MAOIs.
Antifungals: concentration increased by ketoconazole.
Avanafil, vardenafil, sildenafil and tadalafil: enhanced hypotensive effect, avoid concomitant use.
Beta-blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Calcium-channel blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Diuretics: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Moxisylyte: possibly severe postural hypotension.

Metabolism

Tamsulosin is metabolised slowly in the liver primarily by the cytochrome P450 isoenzymes CYP2D6 and CYP3A4; it is excreted mainly in the urine as metabolites and some unchanged drug

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