TanshinoneIIA Chemical Properties

Melting point:

To dark to Visualize

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

Red

Water Solubility 

H2O: 2mg/mL, clear (warmed)

InChI

InChI=1S/C19H18O6S.Na.H/c1-9-13-15(20)16(21)14-10-5-4-8-19(2,3)12(10)7-6-11(14)17(13)25-18(9)26(22,23)24;;/h6-7H,4-5,8H2,1-3H3,(H,22,23,24);;

InChIKey

HJOROJKIZHZOCZ-UHFFFAOYSA-N

SMILES

CC1=C(OC2C3C=CC4C(CCCC=4C=3C(=O)C(=O)C1=2)(C)C)S(O)(=O)=O.[NaH]

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

TanshinoneIIA Usage And Synthesis

Chemical Properties

Red crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the rhizome of Salvia miltiorrhiza.

Uses

Sodium 1,6,6-Trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-sulfonate is an anti-oxidant for ameliorating hemorrhagic shock (HS)-induced organ failure or function. Asthma treatment.

Biological Activity

Tanshinone II A sulfonate is a water-soluble derivative of tanshinone II A th at exhibits anti-inflammatory properties in rodent models of hepatitis and sepsis. Tanshinone II A sulfonate targets Ca2+-activated potassium channels and carboxylesterase 2. Recent studies indicate th at tanshinone II A sulfonate but not tanshinone II A acts as potent negative allosteric modulator of the human purinergic receptor P2X7.

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