Dizocilpine Chemical Properties

Melting point:

68.5-69°

alpha 

20589 +161.4° (c = 0.038 g/2 ml ethanol)

Boiling point:

320.3±11.0 °C(Predicted)

Density 

1.144±0.06 g/cm3(Predicted)

solubility 

Soluble in DMSO > 10 mM

form 

Powder

pka

7.96±0.40(Predicted)

EPA Substance Registry System

5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S,10R)- (77086-21-6)

Safety Information

Hazardous Substances Data

77086-21-6(Hazardous Substances Data)

Dizocilpine Usage And Synthesis

Uses

Neuroprotective.

Definition

ChEBI: Dizocilpine is an organic heterotetracyclic compound that is 1-methyl-8-azabicyclo[3.2.1]octane ortho-fused to two benzene rings at positions 2-3 and 6-7 (the 5S,10R-stereoisomer). It is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor and affects cognitive function, learning, and memory. It has a role as a NMDA receptor antagonist, an anaesthetic, an anticonvulsant, a nicotinic antagonist and a neuroprotective agent. It is a secondary amino compound and a tetracyclic antidepressant. It is a conjugate base of a dizocilpine(1+).

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