Dizocilpine
Dizocilpine Basic information
- Product Name:
- Dizocilpine
- Synonyms:
-
- (5S)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5α,10α-imine
- [5S,10R,(+)]-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine
- [5S,10R,(+)]-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5α,10α-imine
- C13737
- MK-801 (Dizocilpine)
- 5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S,10R)-
- Dizocilpine
- Dizocilpine free base(MK801)
- CAS:
- 77086-21-6
- MF:
- C16H15N
- MW:
- 221.3
- Product Categories:
-
- Inhibitors
- Mol File:
- 77086-21-6.mol
Dizocilpine Chemical Properties
- Melting point:
- 68.5-69°
- alpha
- 20589 +161.4° (c = 0.038 g/2 ml ethanol)
- Boiling point:
- 320.3±11.0 °C(Predicted)
- Density
- 1.144±0.06 g/cm3(Predicted)
- solubility
- Soluble in DMSO > 10 mM
- form
- Powder
- pka
- 7.96±0.40(Predicted)
- color
- White to off-white
- EPA Substance Registry System
- 5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S,10R)- (77086-21-6)
Safety Information
- Hazardous Substances Data
- 77086-21-6(Hazardous Substances Data)
Dizocilpine Usage And Synthesis
Uses
Neuroprotective.
Definition
ChEBI: Dizocilpine is an organic heterotetracyclic compound that is 1-methyl-8-azabicyclo[3.2.1]octane ortho-fused to two benzene rings at positions 2-3 and 6-7 (the 5S,10R-stereoisomer). It is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor and affects cognitive function, learning, and memory. It has a role as a NMDA receptor antagonist, an anaesthetic, an anticonvulsant, a nicotinic antagonist and a neuroprotective agent. It is a secondary amino compound and a tetracyclic antidepressant. It is a conjugate base of a dizocilpine(1+).
in vivo
Dizocilpine maleate can be used to create schizophrenia models. An intraperitoneal injection of 0.2 mg/kg in SD rats results in a half-life of 52.31 minutes, an AUC of 3185.48 nM·min, and a clearance rate of 34 mL/min/kg[2].
Administration: 0.4 mg/kg ? i.p. ? single dose.
Prepulse Inhibition (PPI): Decreased PPI significantly.
maze test:Avoided open arm entries in elevated plus maze test and reduced number of novel arm entries in Y maze test.
IC 50
NMDA Receptor
DizocilpineSupplier
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
- Tel
- 15221275939
- shenlinxing@macklin.cn
- Tel
- 027-59599241 18871490274
- 1400878000@qq.com
- Tel
- 021-52996696，15000506266 15000506266
- Tel
- 21-619849051-1 18521059765
- synchempharma@aliyun.com